Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

The epigenome coordinates spatial-temporal specific gene expression during development
and in adulthood, for the maintenance of homeostasis and upon tissue repair. The upheaval …

Through its involvement in gene transcription and heterochromatin formation, DNA
methylation regulates how cells interact with their environment. Nevertheless, the …

Systemic sclerosis is a fibrotic disease that initiates in the skin and progresses to internal
organs, leading to a poor prognosis. Unraveling the etiology of a chronic, multifactorial …

The epigenetic regulation of nuclear factor erythroid 2-related factor 2 (Nrf2), a pivotal redox
transcription factor, plays a crucial role in maintaining cellular homeostasis. Recent research …

Cells inhabit a mechanical microenvironment that they continuously sense and adapt to. The
plasma membrane (PM), serving as the boundary of the cell, plays a pivotal role in this …

Fibrosis results from excessive extracellular matrix (ECM) deposition, causing tissue
stiffening and organ dysfunction. Activated fibroblasts, central to fibrosis, exhibit increased …

Vasculopathy is a common hallmark of various fibrotic disorders including systemic sclerosis
(SSc), yet its underlying etiology and contribution to fibrogenesis remain ill-defined. In SSc …