COVID-19-associated fungal infections

M Hoenigl, D Seidel, R Sprute, C Cunha… - Nature …, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19)-associated invasive fungal infections are an
important complication in a substantial number of critically ill, hospitalized patients with …

When uncontrolled diabetes mellitus and severe COVID-19 converge: the perfect storm for mucormycosis

TM John, CN Jacob, DP Kontoyiannis - Journal of fungi, 2021 - mdpi.com
Mucormycosis (MCR) has been increasingly described in patients with coronavirus disease
2019 (COVID-19) but the epidemiological factors, presentation, diagnostic certainty, and …

Epidemiology and pathophysiology of COVID-19-associated mucormycosis: India versus the rest of the world

V Muthu, SM Rudramurthy, A Chakrabarti, R Agarwal - Mycopathologia, 2021 - Springer
Abstract The coronavirus disease 2019 (COVID-19) pandemic has led to a concerning
resurgence of mucormycosis. More than 47,000 cases of mucormycosis were reported in …

ECMM/ISHAM recommendations for clinical management of COVID‐19 associated mucormycosis in low‐and middle‐income countries

SM Rudramurthy, M Hoenigl, JF Meis, OA Cornely… - Mycoses, 2021 - Wiley Online Library
Reports are increasing on the emergence of COVID‐19–associated mucormycosis (CAM)
globally, driven particularly by low‐and middle‐income countries. The recent unprecedented …

Pathogenesis of respiratory viral and fungal coinfections

F Salazar, E Bignell, GD Brown, PC Cook… - Clinical Microbiology …, 2022 - Am Soc Microbiol
Individuals suffering from severe viral respiratory tract infections have recently emerged as
“at risk” groups for developing invasive fungal infections. Influenza virus is one of the most …

The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection

AJ Carlos, DP Ha, DW Yeh, R Van Krieken… - Journal of Biological …, 2021 - ASBMB
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
the COVID-19 global pandemic, utilizes the host receptor angiotensin-converting enzyme 2 …

The stress-inducible ER chaperone GRP78/BiP is upregulated during SARS-CoV-2 infection and acts as a pro-viral protein

WJ Shin, DP Ha, K Machida, AS Lee - Nature communications, 2022 - nature.com
The current Coronavirus global pandemic necessitates the search for novel targets and
therapeutic avenues. Shaban et al. 1 reported the use of an endoplasmic reticulum (ER) …

Innate receptor activation patterns involving TLR and NLR synergisms in COVID-19, ALI/ARDS and sepsis cytokine storms: a review and model making novel …

R Root-Bernstein - International journal of molecular sciences, 2021 - mdpi.com
Severe COVID-19 is characterized by a “cytokine storm”, the mechanism of which is not yet
understood. I propose that cytokine storms result from synergistic interactions among Toll …

Coronavirus disease 2019–associated mucormycosis: risk factors and mechanisms of disease

S Narayanan, JV Chua… - Clinical Infectious Diseases, 2022 - academic.oup.com
The severe surge of coronavirus disease 2019 (COVID-19) cases on the Indian
subcontinent in early 2021 was marked by an unusually high number of COVID-19 …

Current understanding in the pathophysiology of SARS-CoV-2-associated rhino-orbito-cerebral mucormycosis: a comprehensive review

A Jose, S Singh, A Roychoudhury, Y Kholakiya… - Journal of maxillofacial …, 2021 - Springer
Aim Recently, with the second wave of COVID-19, the Indian subcontinent has witnessed a
dramatic rise in mucormycosis infection in patients recovered from COVID-19. This …