Spin hyperpolarization in modern magnetic resonance

J Eills, D Budker, S Cavagnero, EY Chekmenev… - Chemical …, 2023 - ACS Publications
Magnetic resonance techniques are successfully utilized in a broad range of scientific
disciplines and in various practical applications, with medical magnetic resonance imaging …

Hyperpolarized NMR Spectroscopy: d‐DNP, PHIP, and SABRE Techniques

KV Kovtunov, EV Pokochueva… - Chemistry–An Asian …, 2018 - Wiley Online Library
The intensity of NMR signals can be enhanced by several orders of magnitude by using
various techniques for the hyperpolarization of different molecules. Such approaches can …

Recent advances in the application of parahydrogen in catalysis and biochemistry

G Buntkowsky, F Theiss, J Lins, YA Miloslavina… - RSC …, 2022 - pubs.rsc.org
Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI)
are analytical and diagnostic tools that are essential for a very broad field of applications …

SABRE: Chemical kinetics and spin dynamics of the formation of hyperpolarization

DA Barskiy, S Knecht, AV Yurkovskaya… - Progress in Nuclear …, 2019 - Elsevier
In this review, we present the physical principles of the SABRE (Signal Amplification By
Reversible Exchange) method. SABRE is a promising hyperpolarization technique that …

Delivering strong 1H nuclear hyperpolarization levels and long magnetic lifetimes through signal amplification by reversible exchange

PJ Rayner, MJ Burns, AM Olaru… - Proceedings of the …, 2017 - National Acad Sciences
Hyperpolarization turns typically weak NMR and MRI responses into strong signals so that
ordinarily impractical measurements become possible. The potential to revolutionize …

Signal amplification by reversible exchange (SABRE): From discovery to diagnosis

PJ Rayner, SB Duckett - Angewandte Chemie International …, 2018 - Wiley Online Library
Signal amplification by reversible exchange (SABRE) turns typically weak magnetic
resonance responses into strong signals making previously impractical measurements …

Perfluorinated Iridium Catalyst for Signal Amplification by Reversible Exchange Provides Metal-Free Aqueous Hyperpolarized [1-13C]-Pyruvate

J Ettedgui, B Blackman, N Raju, SA Kotler… - Journal of the …, 2023 - ACS Publications
Hyperpolarized (HP) carbon-13 [13C] enables the specific investigation of dynamic
metabolic and physiologic processes via in vivo MRI-based molecular imaging. As the …

Generalizing, extending, and maximizing nitrogen-15 hyperpolarization induced by parahydrogen in reversible exchange

JFP Colell, AWJ Logan, Z Zhou… - The Journal of …, 2017 - ACS Publications
Signal Amplification by Reversible Exchange (SABRE) is a fast and convenient NMR
hyperpolarization method that uses cheap and readily available para-hydrogen as a …

Over 20% 15N Hyperpolarization in Under One Minute for Metronidazole, an Antibiotic and Hypoxia Probe

DA Barskiy, RV Shchepin, AM Coffey… - Journal of the …, 2016 - ACS Publications
Direct NMR hyperpolarization of naturally abundant 15N sites in metronidazole is
demonstrated using SABRE-SHEATH (Signal Amplification by Reversible Exchange in …

Fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational N-heterocyclic carbene design

PJ Rayner, P Norcott, KM Appleby, W Iali… - Nature …, 2018 - nature.com
Iridium N-heterocyclic carbene (NHC) complexes catalyse the para-hydrogen-induced
hyperpolarization process, Signal Amplification by Reversible Exchange (SABRE). This …