Proteomics involves the applications of technologies for the identification and quantification
of overall proteins present content of a cell, tissue or an organism. It supplements the other …

Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …

SILAC is based on direct addition of selected stable isotope amino acids into the cell culture
medium, allowing superior quantitative analysis of the cellular proteome compared to other …

Mass spectrometry (MS)-based proteomics is increasingly applied in a quantitative format,
often based on labeling of samples with stable isotopes that are introduced chemically or …

Organisms from all domains of life use gene regulation networks to control cell growth,
identity, function, and responses to environmental challenges. Although accurate global …

We set out to provide a resource to the microbiology community especially with respect to
systems biology based endeavors. To this end, we generated a comprehensive dataset …

Functional genomics of the Gram-positive model organism Bacillus subtilis reveals valuable
insights into basic concepts of cell physiology. In this study, we monitor temporal changes in …

Quantitative mass spectrometry approaches are used for absolute and relative quantification
in global proteome studies. To date, relative and absolute quantification techniques are …

With the advent of the “-omics” era, biological research has shifted from functionally
analyzing single proteins to understanding how entire protein networks connect and adapt …

Recent phosphoproteomics studies have generated relatively large data sets of bacterial
proteins phosphorylated on serine, threonine, and tyrosine, implicating this type of …