In the last several decades, there have been significant advances in anticancer therapy.
However, the development of resistance to cancer drugs and the lack of specificity related to …

Antimicrobial peptides (AMPs) which predominantly act via membrane active mechanisms
have emerged as an exciting class of antimicrobial agents with tremendous potential to …

The incorporation of the innate immune system into humans is essential for survival and
health due to the rapid replication of invading microbes and the delayed action of the …

Infectious diseases caused by bacteria, viruses or fungi are among the leading causes of
death worldwide. The emergence of drug-resistance mechanisms, especially among …

Antimicrobial peptides (AMPs) are usually small molecule peptides, which display broad‐
spectrum antimicrobial activity, high efficiency, and stability. For the multiple‐antibiotic …

The pathogenesis of ulcerative colitis (UC) is associated with severe inflammation, damaged
colonic barriers, increased oxidative stress, and intestinal dysbiosis. The majority of current …

Host defense peptides (HDPs) are important effector molecules of the innate immune system
of vertebrates. These antimicrobial peptides are also present in invertebrates, plants and …

Multidrug-resistant (MDR) bacteria have become a severe threat to community wellbeing.
Conventional antibiotics are getting progressively more ineffective as a consequence of …

In the last few years, antibiotic resistance and, analogously, anticancer drug resistance have
increased considerably, becoming one of the main public health problems. For this reason, it …

Abstract KR-12-a5 is a 12-meric α-helical antimicrobial peptide (AMP) with dual
antimicrobial and anti-inflammatory activities designed from human cathelicidin LL-37. We …