Protein export through the bacterial Sec pathway
A Tsirigotaki, J De Geyter, A Economou… - Nature Reviews …, 2017 - nature.com
The general secretory (Sec) pathway comprises an essential, ubiquitous and universal
export machinery for most proteins that integrate into, or translocate through, the plasma …
export machinery for most proteins that integrate into, or translocate through, the plasma …
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes
TA Rapoport - Nature, 2007 - nature.com
A decisive step in the biosynthesis of many proteins is their partial or complete translocation
across the eukaryotic endoplasmic reticulum membrane or the prokaryotic plasma …
across the eukaryotic endoplasmic reticulum membrane or the prokaryotic plasma …
[HTML][HTML] Sec-and Tat-mediated protein secretion across the bacterial cytoplasmic membrane—distinct translocases and mechanisms
In bacteria, two major pathways exist to secrete proteins across the cytoplasmic membrane.
The general Secretion route, termed Sec-pathway, catalyzes the transmembrane …
The general Secretion route, termed Sec-pathway, catalyzes the transmembrane …
Mechanisms of Sec61/SecY-mediated protein translocation across membranes
E Park, TA Rapoport - Annual review of biophysics, 2012 - annualreviews.org
The Sec61 or SecY channel, a universally conserved protein-conducting channel,
translocates proteins across and integrates proteins into the eukaryotic endoplasmic …
translocates proteins across and integrates proteins into the eukaryotic endoplasmic …
Tail-anchored membrane protein insertion into the endoplasmic reticulum
RS Hegde, RJ Keenan - Nature Reviews Molecular Cell Biology, 2011 - nature.com
Membrane proteins are inserted into the endoplasmic reticulum (ER) by two highly
conserved parallel pathways. The well-studied co-translational pathway uses signal …
conserved parallel pathways. The well-studied co-translational pathway uses signal …
Structure of the Sec61 channel opened by a signal sequence
RM Voorhees, RS Hegde - Science, 2016 - science.org
Secreted and integral membrane proteins compose up to one-third of the biological
proteome. These proteins contain hydrophobic signals that direct their translocation across …
proteome. These proteins contain hydrophobic signals that direct their translocation across …
[HTML][HTML] Co-translational targeting and translocation of proteins to the endoplasmic reticulum
Co-translational protein targeting to the endoplasmic reticulum (ER), represents an
evolutionary-conserved mechanism to target proteins into the secretory pathway. In this …
evolutionary-conserved mechanism to target proteins into the secretory pathway. In this …
A common mechanism of Sec61 translocon inhibition by small molecules
S Itskanov, L Wang, T Junne, R Sherriff, L Xiao… - Nature chemical …, 2023 - nature.com
The Sec61 complex forms a protein-conducting channel in the endoplasmic reticulum
membrane that is required for secretion of soluble proteins and production of many …
membrane that is required for secretion of soluble proteins and production of many …
The Sec translocon mediated protein transport in prokaryotes and eukaryotes
K Denks, A Vogt, I Sachelaru, NA Petriman… - Molecular membrane …, 2014 - Taylor & Francis
Protein transport via the Sec translocon represents an evolutionary conserved mechanism
for delivering cytosolically-synthesized proteins to extra-cytosolic compartments. The Sec …
for delivering cytosolically-synthesized proteins to extra-cytosolic compartments. The Sec …
[HTML][HTML] Protein translocation across the inner membrane of Gram-negative bacteria: the Sec and Tat dependent protein transport pathways
R Kudva, K Denks, P Kuhn, A Vogt, M Müller… - Research in …, 2013 - Elsevier
Gram negative bacteria possess a large variety of protein transport systems, by which
proteins that are synthesised in the cytosol are exported to destinations in the cell envelope …
proteins that are synthesised in the cytosol are exported to destinations in the cell envelope …