β-Carboline alkaloid monomers and dimers: Occurrence, structural diversity, and biological activities

J Dai, W Dan, U Schneider, J Wang - European Journal of Medicinal …, 2018 - Elsevier
Abstract β-Carboline alkaloids are a family of natural and synthetic products with great
structural diversity and outstanding biological activities. This review covers critically …

A review on β-carboline alkaloids and their distribution in foodstuffs: A class of potential functional components or not?

Z Xie, N Cao, C Wang - Food Chemistry, 2021 - Elsevier
Pharmacologically active β-carboline alkaloids (βCs) such as harman, norharman and some
others are naturally present in plants and occur in many foodstuffs. They have a lot of …

Iodine-Catalyzed Synthesis of Benzo-β-carbolines through Desulfurative Cyclization of 2-(1H-Indol-3-ylsulfanyl)-phenylamines with Aryl Methyl Ketones

SS Marupalli, M Arockiaraj, G Singh… - The Journal of …, 2023 - ACS Publications
A novel transition metal-free strategy for the synthesis of benzene-fused β-carboline
scaffolds has been developed. This protocol offers a rapid and direct pathway to access the …

Design, synthesis, anti-cancer evaluation and binding mode studies of benzimidazole/benzoxazole linked β-carboline derivatives

R Sireesha, R Sreenivasulu, C Chandrasekhar… - Journal of Molecular …, 2021 - Elsevier
A new series of benzimidazole/benzoxazole linked β-carbolines (9a-j) were rationally
designed and synthesized by combining two different anti-cancer fragments. The new hybrid …

Antiviral activity of natural and synthetic β-carbolines against dengue virus

VM Quintana, LE Piccini, JDP Zénere, EB Damonte… - Antiviral research, 2016 - Elsevier
Dengue virus (DENV) is the most prevalent mosquito borne viral pathogen worldwide. In this
work we first evaluated the antiviral activity of natural and synthetic β-carbolines against …

Harmine, a small molecule derived from natural sources, inhibits enterovirus 71 replication by targeting NF-κB pathway

D Chen, X Tian, X Zou, S Xu, H Wang, N Zheng… - International …, 2018 - Elsevier
Abstract Enterovirus 71 (EV71) infection of young children can cause neurological
manifestations, which is mainly responsible for the fatality. Although a vaccine is recently …

Synthesis and evaluation of novel hybrids β-carboline-4-thiazolidinones as potential antitumor and antiviral agents

VA Barbosa, P Baréa, RS Mazia… - European journal of …, 2016 - Elsevier
A series of novel hybrids β-carboline-4-thiazolidinones were synthesized and evaluated for
their in vitro antitumor activity against human cancer cell lines and for antiviral activity …

Chromatography-Free Synthesis of β-Carboline 1-Hydrazides and an Investigation of the Mechanism of Their Bioactivity: The Discovery of β-Carbolines as …

T Sheng, C Yu, Y Wang, S Li, H Wu, Q Gu… - Journal of Medicinal …, 2023 - ACS Publications
Agrochemical science prioritizes the discovery and effective synthesis of innovative and
promising lead compounds. Herein, we developed an efficient column chromatography-free …

Medicinal Chemistry Perspectives on the Development of Piperazine-Containing HIV-1 Inhibitors

CA Salubi, HS Abbo, N Jahed, S Titinchi - Bioorganic & Medicinal …, 2024 - Elsevier
The Human immunodeficiency virus (HIV) is the causative agent of acquired
immunodeficiency syndrome (AIDS), one of the most perilous diseases known to …

Palladium-catalyzed imidoylative cyclization of tryptophan-derived isocyanides: Access to β-carbolines

S Tang, J Wang, Z Xiong, Z Xie, D Li, J Huang… - Organic …, 2017 - ACS Publications
A palladium-catalyzed imidoylative cyclization of ethyl-3-(1 H-indol-3-yl)-2-
isocyanopropanoates, derived from readily available tryptophan, to afford β-carboline …