Publisher Summary This chapter discusses the structure and function of the epidermal
growth factor (EGF) receptor (EGFR), from ligand binding to the initiation of intracellular …

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that plays a
critical role in the pathogenesis of many cancers. The structure of intact forms of this receptor …

Genome sequences are now available that enable us to determine the biological
components that make up a cell or an organism. The discipline of systems biology examines …

The erbB/HER family of transmembrane receptor tyrosine kinases (RTKs) mediate cellular
responses to epidermal growth factor (EGF) and related ligands. We have imaged the early …

The epidermal growth factor receptor (EGFR) plays vital roles in cellular processes including
cell proliferation, survival, motility, and differentiation. The dysregulated activation of the …

The study of cellular signalling over the past 20 years and the advent of high-throughput
technologies are enabling the reconstruction of large-scale signalling networks. After careful …

Epidermal growth factor receptor (EGFR) signalling is activated by ligand-induced receptor
dimerization. Notably, ligand binding also induces EGFR oligomerization, but the structures …

Receptor tyrosine kinases (RTKs) play essential roles in cellular processes, including
metabolism, cell-cycle control, survival, proliferation, motility and differentiation. RTKs are all …

Structural studies have provided important new insights into how ligand binding promotes
homodimerization and activation of the EGF receptor and the other members of the ErbB …

Computational models have rarely been used as tools by biologists but, when models
provide experimentally testable predictions, they can be extremely useful. The epidermal …