[HTML][HTML] The anatomy of pain and suffering in the brain and its clinical implications
Pain is an unpleasant sensory and emotional experience associated with actual or potential
tissue damage. Chronic pain, with a prevalence of 20–30% is the major cause of human …
tissue damage. Chronic pain, with a prevalence of 20–30% is the major cause of human …
Role of the prefrontal cortex in pain processing
WY Ong, CS Stohler, DR Herr - Molecular neurobiology, 2019 - Springer
The prefrontal cortex (PFC) is not only important in executive functions, but also pain
processing. The latter is dependent on its connections to other areas of the cerebral …
processing. The latter is dependent on its connections to other areas of the cerebral …
Neocortical circuits in pain and pain relief
LL Tan, R Kuner - Nature Reviews Neuroscience, 2021 - nature.com
The sensory, associative and limbic neocortical structures play a critical role in shaping
incoming noxious inputs to generate variable pain perceptions. Technological advances in …
incoming noxious inputs to generate variable pain perceptions. Technological advances in …
Sex and gender differences in pain
NR Osborne, KD Davis - International Review of Neurobiology, 2022 - Elsevier
Chronic pain affects 20% of adults and is one of the leading causes of disability worldwide.
Women and girls are disproportionally affected by chronic pain. About half of chronic pain …
Women and girls are disproportionally affected by chronic pain. About half of chronic pain …
Interactions between brain and spinal cord mediate value effects in nocebo hyperalgesia
Value information about a drug, such as the price tag, can strongly affect its therapeutic
effect. We discovered that value information influences adverse treatment outcomes in …
effect. We discovered that value information influences adverse treatment outcomes in …
Brainstem mechanisms of pain modulation: a within-subjects 7T fMRI study of placebo analgesic and nocebo hyperalgesic responses
LS Crawford, EP Mills, T Hanson… - Journal of …, 2021 - Soc Neuroscience
Pain perception can be powerfully influenced by an individual's expectations and beliefs.
Although the cortical circuitry responsible for pain modulation has been thoroughly …
Although the cortical circuitry responsible for pain modulation has been thoroughly …
Challenges and opportunities for brainstem neuroimaging with ultrahigh field MRI
The human brainstem plays a central role in connecting the cerebrum, the cerebellum and
the spinal cord to one another, hosting relay nuclei for afferent and efferent signaling, and …
the spinal cord to one another, hosting relay nuclei for afferent and efferent signaling, and …
Mode of action of astrocytes in pain: From the spinal cord to the brain
Y Chen, X Feng, CW Cheung, JA Liu - Progress in Neurobiology, 2022 - Elsevier
Chronic pain is a maladaptive condition affecting 7%− 10% of the population worldwide and
can be accompanied by depression, anxiety, and insomnia. In particular, chronic pain is …
can be accompanied by depression, anxiety, and insomnia. In particular, chronic pain is …
Resting functional connectivity of the periaqueductal gray is associated with normal inhibition and pathological facilitation in conditioned pain modulation
Conditioned pain modulation (CPM), a psychophysical paradigm that is commonly used to
infer the integrity of endogenous pain-altering systems by observation of the effect of one …
infer the integrity of endogenous pain-altering systems by observation of the effect of one …
[HTML][HTML] Functional connectome of arousal and motor brainstem nuclei in living humans by 7 Tesla resting-state fMRI
Brainstem nuclei play a pivotal role in many functions, such as arousal and motor control.
Nevertheless, the connectivity of arousal and motor brainstem nuclei is understudied in …
Nevertheless, the connectivity of arousal and motor brainstem nuclei is understudied in …