This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

The ability to sense physical forces is conserved across all organisms. Cells convert
mechanical stimuli into electrical or chemical signals via mechanically activated ion …

The initial step in the sensory transduction pathway underpinning hearing and balance in
mammals involves the conversion of force into the gating of a mechanosensory transduction …

Progress in deciphering the genetic architecture of human sensorineural hearing
impairment (SNHI) or loss, and multidisciplinary studies of mouse models, have led to the …

Activation of mechanosensitive ion channels underlies a variety of fundamental
physiological processes that require sensation of mechanical force. Different …

The TMEM63 family proteins (A, B, and C), calcium-permeable channels in animals that are
preferentially activated by hypo-osmolality, have been implicated in various physiological …

Many ion channels have been described as mechanosensitive according to various criteria.
Most broadly defined, an ion channel is called mechanosensitive if its activity is controlled by …

Organisms of all phyla express mechanosensitive ion channels with a wide range of
physiological functions. In recent years, several classes of mechanically gated ion channels …

Genetic approaches in the fruit fly, Drosophila melanogaster, have led to a major triumph in
the field of sensory biology—the discovery of multiple large families of sensory receptors …

Summary TMC1 and TMC2 (TMC1/2) have been proposed to form the pore of the
mechanotransduction channel of cochlear hair cells. Here, we show that TMC1/2 cannot …