ATPases associated with diverse cellular activities (AAA+ proteins) are a superfamily of
proteins found throughout all domains of life. The hallmark of this family is a conserved …

Neurons begin their life as simple spheres, but can ultimately assume an elaborate
morphology with numerous, highly arborized dendrites, and long axons. This is achieved via …

Exome sequencing analysis of over 2,000 children with complex malformations of cortical
development identified five independent (four homozygous and one compound …

Microtubules (MTs) are tubular polymers of tubulin that are highly dynamic and found
throughout the cytoplasm. MTs are involved in maintaining cell structure and, together with …

The major cause of death in cancer patients is strongly associated with metastasis. While
much remains to be understood, microtubule-associated proteins (MAPs) have shed light on …

The axonemal central pair (CP) are non-centrosomal microtubules critical for planar ciliary
beat. How they form, however, is poorly understood. Here, we show that mammalian CP …

Abstract Dual-targeting anticancer agents 4–29 are designed by combining the structural
features of purine-type microtubule-disrupting compounds and HDAC inhibitors. A library of …

KATANIN is a well-studied microtubule severing protein affecting microtubule organization
and dynamic properties in higher plants. By regulating mitotic and cytokinetic and cortical …

Katanins are microtubule (MT)-severing AAA proteins with high phylogenetic conservation
throughout the eukaryotes. They have been functionally implicated in processes requiring …

Disrupting microtubule dynamics has emerged as a promising strategy for cancer treatment.
However, drug resistance remains a challenge hindering the development of microtubule …