Our ability to generate bacterial strains with unique and increasingly complex functions has
rapidly expanded in recent times. The capacity for DNA synthesis is increasing and costing …

The ability to rationally engineer microorganisms has been a long-envisioned goal dating
back more than a half-century. With the genomics revolution and rise of systems biology in …

Cells navigate environments, communicate and build complex patterns by initiating gene
expression in response to specific signals. Engineers seek to harness this capability to …

Synthetic biology is bringing together engineers and biologists to design and build novel
biomolecular components, networks and pathways, and to use these constructs to rewire …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

Computation underlies the organization of cells into higher-order structures, for example
during development or the spatial association of bacteria in a biofilm,,. Each cell performs a …

To understand complex biological systems requires the integration of experimental and
computational research—in other words a systems biology approach. Computational …

Engineered systems are often built of recurring circuit modules that carry out key functions.
Transcription networks that regulate the responses of living cells were recently found to obey …

Transcriptional regulation is central to the complex behavior of natural biological systems
and synthetic gene circuits. Platforms for the scalable, tunable, and simple modulation of …

Embryogenesis is remarkably robust to segregating mutations and environmental variation;
under a range of conditions, embryos of a given species develop into stereotypically …