Engineering bacteria for diagnostic and therapeutic applications
Our ability to generate bacterial strains with unique and increasingly complex functions has
rapidly expanded in recent times. The capacity for DNA synthesis is increasing and costing …
rapidly expanded in recent times. The capacity for DNA synthesis is increasing and costing …
A brief history of synthetic biology
The ability to rationally engineer microorganisms has been a long-envisioned goal dating
back more than a half-century. With the genomics revolution and rise of systems biology in …
back more than a half-century. With the genomics revolution and rise of systems biology in …
Principles of genetic circuit design
JAN Brophy, CA Voigt - Nature methods, 2014 - nature.com
Cells navigate environments, communicate and build complex patterns by initiating gene
expression in response to specific signals. Engineers seek to harness this capability to …
expression in response to specific signals. Engineers seek to harness this capability to …
Synthetic biology: applications come of age
AS Khalil, JJ Collins - Nature Reviews Genetics, 2010 - nature.com
Synthetic biology is bringing together engineers and biologists to design and build novel
biomolecular components, networks and pathways, and to use these constructs to rewire …
biomolecular components, networks and pathways, and to use these constructs to rewire …
[图书][B] An introduction to systems biology: design principles of biological circuits
U Alon - 2019 - api.taylorfrancis.com
Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …
engineering approach to systems biology. Alon provides nicely written appendices to …
Robust multicellular computing using genetically encoded NOR gates and chemical 'wires'
Computation underlies the organization of cells into higher-order structures, for example
during development or the spatial association of bacteria in a biofilm,,. Each cell performs a …
during development or the spatial association of bacteria in a biofilm,,. Each cell performs a …
Computational systems biology
H Kitano - Nature, 2002 - nature.com
To understand complex biological systems requires the integration of experimental and
computational research—in other words a systems biology approach. Computational …
computational research—in other words a systems biology approach. Computational …
Structure and function of the feed-forward loop network motif
S Mangan, U Alon - … of the National Academy of Sciences, 2003 - National Acad Sciences
Engineered systems are often built of recurring circuit modules that carry out key functions.
Transcription networks that regulate the responses of living cells were recently found to obey …
Transcription networks that regulate the responses of living cells were recently found to obey …
Tunable and multifunctional eukaryotic transcription factors based on CRISPR/Cas
Transcriptional regulation is central to the complex behavior of natural biological systems
and synthetic gene circuits. Platforms for the scalable, tunable, and simple modulation of …
and synthetic gene circuits. Platforms for the scalable, tunable, and simple modulation of …
Shadow enhancers are pervasive features of developmental regulatory networks
Embryogenesis is remarkably robust to segregating mutations and environmental variation;
under a range of conditions, embryos of a given species develop into stereotypically …
under a range of conditions, embryos of a given species develop into stereotypically …