Role of epigenetics and miRNAs in orofacial clefts

MA Garland, B Sun, S Zhang, K Reynolds… - Birth defects …, 2020 - Wiley Online Library
Orofacial clefts (OFCs) have multiple etiologies and likely result from an interplay between
genetic and environmental factors. Within the last decade, studies have implicated specific …

MicroRNAs and gene regulatory networks related to cleft lip and palate

C Iwaya, A Suzuki, J Iwata - International Journal of Molecular Sciences, 2023 - mdpi.com
Cleft lip and palate is one of the most common congenital birth defects and has a complex
etiology. Either genetic or environmental factors, or both, are involved at various degrees …

A developmental stage-specific network approach for studying dynamic co-regulation of transcription factors and microRNAs during craniofacial development

F Yan, P Jia, H Yoshioka, A Suzuki, J Iwata… - …, 2020 - journals.biologists.com
Craniofacial development is regulated through dynamic and complex mechanisms that
involve various signaling cascades and gene regulations. Disruption of such regulations can …

MicroRNAs in maxillofacial bone modeling and remodeling: implications for malocclusion development and orthodontic treatment

B Chen, Y Zhang, O Liu - Frontiers in Cell and Developmental Biology, 2024 - frontiersin.org
Modeling and remodeling are essential processes in the development and refinement of
maxillofacial bones. Dysregulated bone modeling during the developmental stage may lead …

Sasa veitchii extracts protect phenytoin-induced cell proliferation inhibition in human lip mesenchymal cells through modulation of miR-27b-5p

Y Tsukiboshi, A Ogata, A Noguchi, Y Mikami… - Biomedical …, 2023 - jstage.jst.go.jp
ABSTRACT A cleft lip, with or without a cleft palate, is a common birth defect caused by
environmental factors or genetic mutations. Environmental factors, such as pharmaceutical …

[HTML][HTML] Automatic landmarking identifies new loci associated with face morphology and implicates Neanderthal introgression in human nasal shape

Q Li, J Chen, P Faux, ME Delgado, B Bonfante… - Communications …, 2023 - nature.com
We report a genome-wide association study of facial features in> 6000 Latin Americans
based on automatic landmarking of 2D portraits and testing for association with inter …

[HTML][HTML] Genetic etiology of cleft lip and cleft palate

ANMI Khan, CS Prashanth, N Srinath - AIMS Molecular Science, 2020 - aimspress.com
Genetic studies in humans have demonstrated that Cleft lip with or without cleft palate (CL/P)
have a diverse genetic background and probably environmental factors influencing these …

LINC00473 contributes to the radioresistance of esophageal squamous cell carcinoma by regulating microRNA-497-5p and cell division cycle 25A

WH Liu, HY Qiao, J Xu… - International …, 2020 - spandidos-publications.com
Long non-coding RNA (lncRNA) LINC00473 plays a carcinogenic role in a variety of
different tumor types. Nevertheless, the mechanisms through which LINC00473 regulates …

FaceBase: a community-driven hub for data-intensive research

RE Schuler, A Bugacov, JG Hacia… - Journal of Dental …, 2022 - journals.sagepub.com
The FaceBase Consortium, funded by the National Institute of Dental and Craniofacial
Research of the National Institutes of Health, was established in 2009 with the recognition …

[HTML][HTML] Transcriptional and Translational Regulation of Differentially Expressed Genes in Yucatan Miniswine Brain Tissues following Traumatic Brain Injury

V Rai, Y Mendoza-Mari, MM Radwan… - … of bioinformatics and …, 2024 - ncbi.nlm.nih.gov
Traumatic brain injury (TBI) is a leading cause of morbidity, disability, and mortality
worldwide. Motor and cognitive deficits and emotional disturbances are long-term …