Our understanding of depression and its treatment has advanced with the advent of
ketamine as a rapid-acting antidepressant and the development and refinement of tools …

Mood disorders such as depression and anxiety are frequently observed in patients
suffering from chronic pain. Over time, different tests and models have been developed in …

Early-life inflammation increases the risk for depression in later life. Here, we demonstrate
how early-life inflammation causes adolescent depressive-like symptoms: by altering the …

Background Inflammasomes have been found to interact with the gut microbiota, and this
effect is associated with depression, but the mechanisms underlying this interaction have not …

While depression and chronic pain are frequently comorbid, underlying neuronal circuits
and their psychopathological relevance remain poorly defined. Here we show in mice that …

Over the past 20 years, clinical and preclinical studies point to the anterior cingulate cortex
(ACC) as a site of interest for several neurological and psychiatric conditions. The ACC …

Abstract Background N 6-methyladenosine (m 6 A) is the most abundant epigenetic
modification in eukaryotic messenger RNAs and is essential for multiple RNA processing …

Pain associates both sensory and emotional aversive components, and often leads to
anxiety and depression when it becomes chronic. Here, we characterized, in a mouse …

The increasing number of individuals with comorbidities poses an urgent need to improve
the management of patients with multiple co-existing diseases. Among these comorbidities …

A growing number of epidemiological and experimental studies has established that
circadian disruption is strongly associated with psychiatric disorders, including major …