The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

The transcriptome of every cell is orchestrated by the complex network of interaction
between transcription factors (TFs) and their binding sites on DNA. Disruption of this network …

DNA can determine where and when genes are expressed, but the full set of sequence
determinants that control gene expression is unknown. Here, we measured the …

Although genome sequencing has identified numerous noncoding alterations between
primate species, which of those are regulatory and potentially relevant to the evolution of the …

What made us human? Gene expression changes clearly played a significant part in human
evolution, but pinpointing the causal regulatory mutations is hard. Comparative genomics …

Cell-specific expression of many genes is conveyed by multiple enhancers, with each
individual enhancer controlling a particular expression domain. In contrast, multiple …

The form that an animal takes during development is directed by gene regulatory networks
(GRNs). Developmental GRNs interpret maternally deposited molecules and externally …

Empirical models of sequence evolution have spurred progress in the field of evolutionary
genetics for decades. We are now realizing the importance and complexity of the eukaryotic …

Alternative translation initiation and stop codon readthrough in a few well-studied cases
have been shown to allow the same transcript to generate multiple protein variants. Because …

Simple Summary The cancer genome has been exhaustively studied upon the advent of
Next-Generation Sequencing technologies. Coding and non-coding sequences have been …