Mechanical Activation by Ball Milling as a Strategy to Prepare Highly Soluble Pharmaceutical Formulations in the Form of Co-Amorphous, Co-Crystals, or Polymorphs

LM Martínez, J Cruz-Angeles, M Vázquez-Dávila… - Pharmaceutics, 2022 - mdpi.com
Almost half of orally administered active pharmaceutical ingredients (APIs) have low
solubility, which affects their bioavailability. In the last two decades, several alternatives …

Comparative assessment of solubility enhancement of itroconazole by solid dispersion and co-crystallization technique: Investigation of simultaneous effect of media …

K Rajbhar, GR Karodadeo, V Kumar… - Annales …, 2023 - Elsevier
Solubility of the drug is an important property of the drug as it affects the release, absorption,
dissolution rate and ultimately bioavailability of the drug. Hence, the poorly aqueous soluble …

Unraveling the competitive cocrystallization behavior of natural products and impact of intermolecular interactions on their stability

D Li, Z Ning, Z Gong, L Zhou, L Xu, H Shehzad… - Separation and …, 2024 - Elsevier
Abstract Design of natural product cocrystals and its formation mechanism are of great
significance importance to the development of fields such as medicine, food, cosmetics, and …

[HTML][HTML] Modification of physicochemical properties of active pharmaceutical ingredient by pharmaceutical Co-crystals

R Thenge, V Adhao, G Mehetre, N Chopade… - Drug Formulation …, 2023 - intechopen.com
The oral drug delivery is widely used and accepted routes of administration, but it fails to
provide the therapeutic effectiveness of drugs due to low solubility, poor compression and …

Co-crystallization of quercetin and isonicotinamide using solvent evaporation method

B Wisudyaningsih, D Setyawan - Tropical Journal of Pharmaceutical …, 2019 - ajol.info
Purpose: To obtain quercetin-isonicotinamide co-crystal (CQINA) with improved
physicochemical and in-vitro dissolution characteristics. Methods: Co-crystallization of …

Distinguishing polymorphs of ethenzamide-saccharin cocrystal based on terahertz and Raman vibrational spectroscopic techniques

Y Jing, J Zhang, M Wan, J Xue, J Liu… - IEEE Transactions …, 2024 - ieeexplore.ieee.org
In this article, two kinds of pharmaceutical crystallized polymorphs of ethenzamide (ETZ) and
saccharin (SAC) cocrystal were synthesized by both solution crystallization and solid-state …

[PDF][PDF] Archive of SID. ir

MM Mathkoor, EN Alkhfaji, NAU Oda - 2023 - sid.ir
Pure compounds from natural sources or pure plant extracts can be considered as sources
for newer drugs [1]. World Health Organization (WHO) considered that about 80% of humans …

PEMBENTUKAN DAN KARAKTERISASI FISIKA KIMIA KO-KRISTAL PIROXICAM-ASAM TARTRAT-SAKARIN DENGAN METODE SOLVENT DROP GRINDING

T Imanto, HK Pertiwi… - Journal of Islamic …, 2023 - ejournal.uin-malang.ac.id
Piroxicam merupakan obat turunan asam enolat (oksikam) sebagai antiinflamasi nonsteroid
(NSAID). Piroxicam digunakan untuk mengurangi atau menghilangkan resiko rheumatoid …

Medical Thermology 2018-a computer-assisted literature survey.

K Ammer - Thermology International, 2019 - search.ebscohost.com
The literature survey 2018 is based on 719 papers found in Scopus and 65 additional notes
or abstracts detected in the journal" Thermology international" with the keywords" …

An Insilco approach on Trachyspermum Ammi to Discover a Drug that Reduces the Burden of Gallstone and Gallbladder Tumor

B Arirudran - Asian Journal of Medicine and Biomedicine, 2024 - journal.unisza.edu.my
Nowadays, after pandemic circumstances peoples from developing countries and in
particular Indians have faith towards herbal medicine to treat chronic disorders. Based on …