Circadian rhythms and sleep are fundamental biological processes integral to human
health. Their disruption is associated with detrimental physiological consequences …

Aim Symptoms of bipolar disorder (BD) include changes in mood, activity, energy, sleep,
and appetite. Since many of these processes are regulated by circadian function, circadian …

Many chronic disease symptomatologies involve desynchronized sleep-wake cycles,
indicative of disrupted biorhythms. This can be interrogated using body temperature …

Chronic pain is highly prevalent worldwide and represents a significant socioeconomic and
public health burden. Several aspects of chronic pain, for example back pain and a severity …

Background Sleep problems are both symptoms of and modifiable risk factors for many
psychiatric disorders. Wrist-worn accelerometers enable objective measurement of sleep at …

Sleep, circadian rhythms, and mental health are reciprocally interlinked. Disruption to the
quality, continuity, and timing of sleep can precipitate or exacerbate psychiatric symptoms in …

Major mood syndromes are among the most common and disabling mental disorders.
However, a lack of clear delineation of their underlying pathophysiological mechanisms is a …

Longitudinal studies associate shiftwork with cardiometabolic disorders but do not establish
causation or elucidate mechanisms of disease. We developed a mouse model based on …

A growing number of epidemiological and experimental studies has established that
circadian disruption is strongly associated with psychiatric disorders, including major …

Evening-oriented sleep timing preferences have been associated with risk of diabetes,
cardiovascular diseases, obesity, psychiatric disorders, and increased mortality. This …