The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6)
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …

Aging is associated with age-related diseases and an increase susceptibility of cancer.
Dissecting the molecular mechanisms that underlie aging and longevity would contribute to …

Significance: Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide
that serves as an essential cofactor and substrate for a number of critical cellular processes …

DAF-16, the only forkhead box transcription factors class O (FoxO) homolog in
Caenorhabditis elegans, integrates signals from upstream pathways to elicit transcriptional …

Forkhead box O (FOXO) transcription factors (TFs) are a subclass of the larger family of
forkhead TFs. Mammalians express four members FOXO1, FOXO3, FOXO4, and FOXO6 …

In post-reproductive C. elegans, destructive somatic biomass repurposing supports
production of yolk which, it was recently shown, is vented and can serve as a foodstuff for …

Aging is a universal phenomenon in all biological organisms, defined by the loss of
reproductive capacity and a progressive decline in fitness. In humans, aging is further …

The goal of aging research is to extend healthy, active life. For decades, C. elegans daf-2
insulin/insulin-like growth factor 1 (IGF-1) receptor mutants have served as a model for …

As Western diets continue to include an ever-increasing amount of sugar, there has been a
rise in obesity and type 2 diabetes. To avoid metabolic diseases, the body must maintain …

Functional state of intestinal barrier plays an important role for environmental animals in
being against various toxicants. We investigated GATA transcriptional factor ELT-2-mediated …