Protein homeostasis (proteostasis) requires the timely degradation of misfolded proteins and
their aggregates by protein quality control (PQC), of which molecular chaperones are an …

The N‐end rule relates the regulation of the in vivo half‐life of a protein to the identity of its N‐
terminal residue. Degradation signals (degrons) that are targeted by the N‐end rule pathway …

Macroautophagy mediates the selective degradation of proteins and non-proteinaceous
cellular constituents. Here, we show that the N-end rule pathway modulates …

The N-end rule pathway is a proteolytic system in which N-terminal residues of short-lived
proteins are recognized by recognition components (N-recognins) as essential components …

We show that ATE1-encoded Arg-transfer RNA transferase (R-transferase) of the N-end rule
pathway mediates N-terminal arginylation of multiple endoplasmic reticulum (ER)-residing …

The N-end rule defines the protein-destabilizing activity of a given amino-terminal residue
and its post-translational modification. Since its discovery 25 years ago, the pathway …

The N-degron pathway is a degradative system in which the N-terminal residues of proteins
modulate the half-lives of proteins and other cellular materials. The majority of amino acids …

The ubiquitin proteasome system (UPS) plays a crucial role in biological processes integral
to the development of the cardiovascular system and cardiovascular diseases. The UPS …

UBR box E3 ligases, also called N-recognins, are integral components of the N-degron
pathway. Representative N-recognins include UBR1, UBR2, UBR4, and UBR5, and they …

The N-end rule pathway is a ubiquitin-dependent system where E3 ligases called N-
recognins, including UBR1 and UBR2, recognize type-1 (basic) and type-2 (bulky …