Leukotrienes (LT) are a class of inflammatory mediators produced by the 5-lipoxygenase (5-
LO) enzyme from arachidonic acid (AA). We discussed the various LT inhibitors and …

Oxidative stress is considered a key factor contributing to the initiation and development of
cardiac injury following ischaemia‒reperfusion (I/R). Arachidonate 5-lipoxygenase (ALOX5) …

Summary In COVID-19, the lipid-mediator storm promotes thromboinflammation, ischemia–
reperfusion injury and cytotoxicity. The thromboxane A 2 and PGD 2 signaling presents a …

Background: An in-depth understanding of the fundamental principles that regulate thyroid
hormone homeostasis is critical for the development of new diagnostic and treatment …

Aims: Endotoxemic shock is characterized by multiple organ dysfunction, acute Lung Injury,
acute respiratory distress syndrome, and high mortality. This study aimed to investigate the …

The role of albumin overload in proximal tubules (PT) in the development of tubulointerstitial
injury and, consequently, in the progression of renal disease has become more relevant in …

Cysteinyl leukotrienes released by mast cells trigger the symptoms of asthma, including
bronchoconstriction and vasoconstriction. Therefore, effective leukotriene inhibitors were …

According to World Health Organization estimates, sepsis affects 30 million or more people
each year, resulting in 6 million deaths worldwide and 1 million in newborns [1] …

Background: It is well known that the hippocampus, the CA1 Pyramidal cells in particular, is
selectively vulnerable during global cerebral ischemia. Recently, it is observed that …

The aim: This study was set out to assess the potential protective impact of MK0752 (a
gamma secretase inhibitor) on sepsis-induced renal injury through modulation of …