The fluorescence-based real-time reverse transcription PCR (RT-PCR) is widely used for the
quantification of steady-state mRNA levels and is a critical tool for basic research, molecular …

Controversy has surrounded a role for apoptosis in the loss of neurons in Parkinson's
disease (PD). Although a variety of evidence has supported an apoptotic contribution to PD …

A unifying feature of many neurodegenerative disorders is the accumulation of
polyubiquitinated protein inclusions in dystrophic neurons, eg containing α-synuclein, which …

Careful normalization is essential for the accurate quantitation of mRNA levels in biopsy-
sized tissue samples. Commonly, normalization of the target gene with an endogenous …

Human cells are exposed to numerous exogenous and endogenous insults every day.
Unlike other molecules, DNA cannot be replaced by resynthesis, hence damage to DNA can …

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) participates in a cell death cascade
wherein a variety of stimuli activate nitric oxide (NO) synthases with NO nitrosylating …

purpose. Based on the evidence of an amplified production of reactive oxygen species
(ROS) during glaucomatous neurodegeneration, proteomic analysis was performed to …

Single-gene disorders with" simple" Mendelian inheritance do not always imply that there
will be an easy prediction of the phenotype from the genotype, which has been shown for a …

Brain banks are facilities providing an interface between generous donation of nervous
tissues and research laboratories devoted to increase our understanding of the diseases of …

Abstract The neurotoxin 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine (MPTP) induces
selective loss of dopaminergic neurons in the mammalian midbrain, eliciting symptoms …