Hepatocyte differentiation, proliferation, and apoptosis are affected by growth factors
produced in liver. Insulin-like growth factor 1 and 2 (IGF1 and IGF2) act in response to …

Consistent evidence associates IGF-1 deficiency and metabolic syndrome. In this review, we
will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its …

Obesity and liver diseases are associated with the disruption of the circadian clock that
orchestrates mammalian physiology to optimize nutrient metabolism and storage. Here, we …

Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in
response to the endocrine GH stimulus, but it is also secreted by multiple tissues for …

Gonadal function is significantly affected in many acute and chronic systemic diseases. As
the function of the testes and the ovaries is determined by the integrity of the hypothalamic …

Methotrexate (MTX) is an anti-metabolite widely used in the treatment of neoplastic
disorders, rheumatoid arthritis and psoriasis. The basis for its therapeutic efficacy is the …

We established an efficient system for differentiation, expansion and isolation of hepatic
progenitor cells from mouse embryonic stem (ES) cells and evaluated their capacity to …

Serum IGF-I levels decline with age. We have recently reported that in aging rats the
exogenous administration of IGF-I restores IGF-I circulating levels and age related-changes …

Parkinson's disease (PD) is a neurodegenerative disorder that results in the death of
dopaminergic neurons within the substantia nigra pars compacta and the reduction in …

BACKGROUND/AIMS: Insulin-like growth factor I (IGF-I) is an anabolic hormone synthesized
in the liver whose levels decrease sharply in liver cirrhosis. METHODS: We conducted a …