Gene therapy has emerged as a promising therapeutic strategy for various conditions,
including blood disorders, ocular disease, cancer, and nervous system disorders. The …

Presenilin 1 (PSEN1) is a part of the gamma secretase complex with several interacting
substrates, including amyloid precursor protein (APP), Notch, adhesion proteins and beta …

Background Aberrant DNA methylation patterns have been observed in neurodegenerative
diseases, including Alzheimer's disease (AD), and dynamic changes in DNA methylation are …

Presenilin, a transmembrane protein primarily known for its role in Alzheimer's disease (AD)
as part of the γ-secretase complex, has garnered increased attention due to its multifaceted …

Amyloid precursor protein (APP) is a membrane protein expressed in several tissues. The
occurrence of APP is predominant in synapses of nerve cells. It acts as a cell surface …

Highlights•Lack of a cure for AD has prompted the exploration of novel therapeutic
approaches.•CRISPR-Cas9 could be a tool for AD therapeutics by correcting faulty …

Sažetak It's been 10 years now from the debut of clustered regularly interspaced short
palindromic repeats-associated protein 9 (CRISPR/Cas9) era in which gene engineering …

We reviewed recent major clinical trials with investigational drugs for the treatment of
subjects with neurodegenerative diseases caused by inheritance of gene mutations or …

Alzheimer's disease (AD) is the most common cause of neurodegenerative impairment in
elderly people. Clinical characteristics include short-term memory loss, confusion …

The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-
associated (Cas) nucleases system (CRISPR/Cas9) is a popular gene-editing technology …