[HTML][HTML] The genomic and transcriptional landscape of primary central nervous system lymphoma
Primary lymphomas of the central nervous system (PCNSL) are mainly diffuse large B-cell
lymphomas (DLBCLs) confined to the central nervous system (CNS). Molecular drivers of …
lymphomas (DLBCLs) confined to the central nervous system (CNS). Molecular drivers of …
[HTML][HTML] Comprehensive genomic and epigenomic analysis in cancer of unknown primary guides molecularly-informed therapies despite heterogeneity
L Möhrmann, M Werner, M Oleś, A Mock… - Nature …, 2022 - nature.com
The benefit of molecularly-informed therapies in cancer of unknown primary (CUP) is
unclear. Here, we use comprehensive molecular characterization by whole genome/exome …
unclear. Here, we use comprehensive molecular characterization by whole genome/exome …
[HTML][HTML] Genomic insights into the pathogenesis of Epstein–Barr virus-associated diffuse large B-cell lymphoma by whole-genome and targeted amplicon sequencing
N Gebauer, A Künstner, J Ketzer, HM Witte… - Blood cancer …, 2021 - nature.com
Abstract Epstein–Barr virus (EBV)-associated diffuse large B-cell lymphoma not otherwise
specified (DLBCL NOS) constitute a distinct clinicopathological entity in the current World …
specified (DLBCL NOS) constitute a distinct clinicopathological entity in the current World …
[HTML][HTML] Comprehensive genomic and tumour immune profiling reveals potential therapeutic targets in malignant pleural mesothelioma
Background Malignant pleural mesothelioma (MPM) has a poor overall survival with few
treatment options. Whole genome sequencing (WGS) combined with the immune features of …
treatment options. Whole genome sequencing (WGS) combined with the immune features of …
Genomic characterization reveals distinct mutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract
H Wu, Z Yu, Y Liu, L Guo, L Teng, L Guo… - Cancer …, 2022 - Wiley Online Library
Background Neuroendocrine carcinomas of the gastrointestinal tract (GI‐NECs) remain a
disease of grim prognosis with limited therapeutic options. Their molecular characteristics …
disease of grim prognosis with limited therapeutic options. Their molecular characteristics …
[HTML][HTML] Transitioning the molecular tumor board from proof of concept to clinical routine: a German single-center analysis
R Hoefflin, A Lazarou, ME Hess, M Reiser, J Wehrle… - Cancers, 2021 - mdpi.com
Simple Summary Access to molecular cancer treatments outside of clinical trials is limited
and the benefit of molecular-guided, individualized patient care in patients with cancer …
and the benefit of molecular-guided, individualized patient care in patients with cancer …
[HTML][HTML] A potential treatment option for transformed small-cell lung cancer on PD-L1 inhibitor-based combination therapy improved survival
CY Zhang, H Sun, JW Su, YQ Chen, SL Zhang… - Lung Cancer, 2023 - Elsevier
Objectives Transformed small-cell lung cancer (T-SCLC) has an extremely poor prognosis,
and no remedies based on immunotherapy have been evaluated among T-SCLC patients …
and no remedies based on immunotherapy have been evaluated among T-SCLC patients …
[HTML][HTML] NCT/DKFZ MASTER handbook of interpreting whole-genome, transcriptome, and methylome data for precision oncology
A Mock, MV Teleanu, S Kreutzfeldt, CE Heilig… - NPJ Precision …, 2023 - nature.com
Abstract Analysis of selected cancer genes has become an important tool in precision
oncology but cannot fully capture the molecular features and, most importantly …
oncology but cannot fully capture the molecular features and, most importantly …
[HTML][HTML] MIRACUM-pipe: an adaptable pipeline for next-generation sequencing analysis, reporting, and visualization for clinical decision making
P Metzger, ME Hess, A Blaumeiser, T Pauli… - Cancers, 2023 - mdpi.com
Simple Summary Next-generation sequencing (NGS) is a cutting-edge technology that
enables rapid, high-throughput sequencing of DNA and RNA. Researchers and clinicians …
enables rapid, high-throughput sequencing of DNA and RNA. Researchers and clinicians …
[HTML][HTML] MC38 colorectal tumor cell lines from two different sources display substantial differences in transcriptome, mutanome and neoantigen expression
B Schrörs, BJ Hos, IG Yildiz, M Löwer, F Lang… - Frontiers in …, 2023 - frontiersin.org
Introduction The cell line MC38 is a commonly used murine model for colorectal carcinoma.
It has a high mutational burden, is sensitive to immune checkpoint immunotherapy and …
It has a high mutational burden, is sensitive to immune checkpoint immunotherapy and …