Symbionts and gene drive: two strategies to combat vector-borne disease

GH Wang, J Du, CY Chu, M Madhav, GL Hughes… - Trends in Genetics, 2022 - cell.com
Mosquitoes bring global health problems by transmitting parasites and viruses such as
malaria and dengue. Unfortunately, current insecticide-based control strategies are only …

Gene drive and symbiont technologies for control of mosquito-borne diseases

GH Wang, A Hoffmann… - Annual Review of …, 2024 - annualreviews.org
Mosquito-borne diseases, such as dengue and malaria, pose a significant burden to global
health. Current control strategies with insecticides are only moderately effective. Scalable …

[图书][B] Insect physiology and biochemistry

JL Nation Sr - 2022 - taylorfrancis.com
Employing the clear, student-friendly style that made previous editions so popular, Insect
Physiology and Biochemistry, Fourth Edition presents an engaging and authoritative guide …

Altering traits and fates of wild populations with Mendelian DNA sequence modifying Allele Sails

ML Johnson, BA Hay, M Maselko - Nature Communications, 2024 - nature.com
Population-scale genome modification can alter the composition or fate of wild populations.
Synthetic gene drives provide one set of tools, but their use is complicated by scientific …

Anopheles homing suppression drive candidates exhibit unexpected performance differences in simulations with spatial structure

SE Champer, IK Kim, AG Clark, PW Messer, J Champer - Elife, 2022 - elifesciences.org
Recent experiments have produced several Anopheles gambiae homing gene drives that
disrupt female fertility genes, thereby eventually inducing population collapse. Such drives …

Suppression gene drive in continuous space can result in unstable persistence of both drive and wild‐type alleles

J Champer, IK Kim, SE Champer, AG Clark… - Molecular …, 2021 - Wiley Online Library
Rapid evolutionary processes can produce drastically different outcomes when studied in
panmictic population models vs. spatial models. One such process is gene drive, which …

Knockout of the odorant receptor co-receptor, orco, impairs feeding, mating and egg-laying behavior in the fall armyworm Spodoptera frugiperda

H Sun, LA Bu, SC Su, D Guo, CF Gao, SF Wu - Insect Biochemistry and …, 2023 - Elsevier
The olfactory transduction system of insects is involved in multiple behavioral processes
such as foraging, mating, and egg-laying behavior. In the insect olfactory receptor neurons …

[PDF][PDF] A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles

E Yang, M Metzloff, AM Langmüller, X Xu, AG Clark… - G3, 2022 - academic.oup.com
Gene drives are engineered alleles that can bias inheritance in their favor, allowing them to
spread throughout a population. They could potentially be used to modify or suppress pest …

Incorporating ecology into gene drive modelling

J Kim, KD Harris, IK Kim, S Shemesh… - Ecology …, 2023 - Wiley Online Library
Gene drive technology, in which fast‐spreading engineered drive alleles are introduced into
wild populations, represents a promising new tool in the fight against vector‐borne diseases …

Population suppression by release of insects carrying a dominant sterile homing gene drive targeting doublesex in Drosophila

W Chen, J Guo, Y Liu, J Champer - Nature Communications, 2024 - nature.com
CRISPR homing gene drives can suppress pest populations by targeting female fertility
genes, converting wild-type alleles into drive alleles in the germline of drive heterozygotes …