Acting as a bridge between the cytoskeleton of the cell and the extra cellular matrix (ECM),
the cell-ECM adhesions with integrins at their core, play a major role in cell signalling to …

Osteoclasts and osteoblasts play a major role in bone tissue homeostasis. The homeostasis
and integrity of bone tissue are maintained by ensuring a balance between osteoclastic and …

Objectives The main target of current drugs for alleviating bone loss is osteoclasts. However,
the long‐term application of such drugs will also cause side effects. Therefore, it is of great …

Improving revascularization is one of the major measures in fracture treatment. Moderate
local inflammation triggers angiogenesis, whereas systemic inflammation hampers …

Ubiquitin-conjugating enzyme E2 M (UBE2M) and ubiquitin-conjugating enzyme E2 F
(UBE2F) are the two NEDD8-conjugating enzymes of the neddylation pathway that take part …

Objectives Aging and common diseases alter the stiffness of bone tissue, causing changes
to the microenvironment of the mechanosensitive bone cells. Osteoclasts, the sole bone …

Macrophages and osteoclasts are both derived from monocyte/macrophage lineage, which
plays as the osteoclastic part of bone metabolism. Although they are regulated by bone …

Pyk2 is a non-receptor tyrosine kinase highly enriched in forebrain neurons. Pyk2 is closely
related to focal adhesion kinase (FAK), which plays an important role in sensing cell …

Triple-negative breast cancer (TNBC) is heterogeneous and aggressive, with high
vascularity and frequent metastasis. We have already found natural flavonoid scutellarin …

Osteoclast is a hematopoietic precursor cell derived from the mononuclear macrophage cell
line, which is the only cell with bone resorption function. Its abnormal activation can cause …