[HTML][HTML] Treatment of overdose in the synthetic opioid era

P Skolnick - Pharmacology & therapeutics, 2022 - Elsevier
Overdose deaths are often viewed as the leading edge of the opioid epidemic which has
gripped the United States over the past two decades (Skolnick, 2018a). This emphasis is …

Fentanyl: Receptor pharmacology, abuse potential, and implications for treatment

SD Comer, CM Cahill - Neuroscience & Biobehavioral Reviews, 2019 - Elsevier
Opioid overdoses, many of which are attributed to use of illicit fentanyl, are currently one of
the leading causes of death in the US Although fentanyl has been used safely for decades in …

[HTML][HTML] The triple wave epidemic: supply and demand drivers of the US opioid overdose crisis

D Ciccarone - International Journal of Drug Policy, 2019 - Elsevier
The US mortality rate has gone up three years in a row from 2014 to 2017 (Xu, Murphy,
Kochanek, & Arias, 2016; Murphy, Xu, Kochanek, & Arias, 2018; Kochanek, Murphy, Xu, & …

Management of opioid use disorders: a national clinical practice guideline

J Bruneau, K Ahamad, MÈ Goyer, G Poulin, P Selby… - Cmaj, 2018 - Can Med Assoc
Methods The Canadian Research Initiative in Substance Misuse (CRISM), a Canadian
Institutes of Health Research (CIHR)–funded research network composed of four regional …

Tackling the overdose crisis: the role of safe supply

A Ivsins, J Boyd, L Beletsky, R McNeil - International Journal of Drug Policy, 2020 - Elsevier
North America is experiencing an unprecedented overdose crisis driven by the proliferation
of fentanyl and its analogues in the illicit drug supply. In 2018 there were 67,367 drug …

Opioid-related mortality in rural America: Geographic heterogeneity and intervention strategies

KK Rigg, SM Monnat, MN Chavez - International Journal of Drug Policy, 2018 - Elsevier
Over the last two decades, opioid-related mortality rates have increased dramatically to
become a serious public health concern in the United States. Opioid-related mortality has …

Modeling the evolution of the US opioid crisis for national policy development

TY Lim, EJ Stringfellow, CA Stafford… - Proceedings of the …, 2022 - National Acad Sciences
The opioid crisis is a major public health challenge in the United States, killing about 70,000
people in 2020 alone. Long delays and feedbacks between policy actions and their effects …

Opioids after surgery in the United States versus the rest of the world: the International Patterns of Opioid Prescribing (iPOP) multicenter study

HMA Kaafarani, K Han, M El Moheb… - Annals of …, 2020 - journals.lww.com
Objective: The International Patterns of Opioid Prescribing study compares postoperative
opioid prescribing patterns in the United States (US) versus the rest of the world. Summary …

The rising crisis of illicit fentanyl use, overdose, and potential therapeutic strategies

Y Han, W Yan, Y Zheng, MZ Khan, K Yuan… - Translational psychiatry, 2019 - nature.com
Fentanyl is a powerful opioid anesthetic and analgesic, the use of which has caused an
increasing public health threat in the United States and elsewhere. Fentanyl was initially …

Opioid agonist treatment and risk of mortality during opioid overdose public health emergency: population based retrospective cohort study

LA Pearce, JE Min, M Piske, H Zhou, F Homayra… - Bmj, 2020 - bmj.com
Objective To compare the risk of mortality among people with opioid use disorder on and off
opioid agonist treatment (OAT) in a setting with a high prevalence of illicitly manufactured …