Spinal cord injury can lead to severe motor, sensory and autonomic dysfunction. Currently,
there is no effective treatment for the injured spinal cord. The transplantation of Schwann …

Cell transplantation holds immense potential for reversing diseases that are currently
incurable and for regenerating tissues. However, poor cell survival, cell aggregation and …

Neural stem cells (NSCs) expressing GFP were embedded into fibrin matrices containing
growth factor cocktails and grafted to sites of severe spinal cord injury. Grafted cells …

To model human neural-cell-fate specification and to provide cells for regenerative
therapies, we have developed a method to generate human neural progenitors and neurons …

Axons in the mammalian CNS fail to regenerate after injury. Here we show that if the activity
of mouse retinal ganglion cells (RGCs) is increased by visual stimulation or using …

For many decades, the inability of lesioned central neurons to regrow was accepted almost
as a" law of nature", and on the clinical level, spinal cord and brain lesions were seen as …

Recent advances in deriving induced pluripotent stem (iPS) cells from patients offer new
possibilities for biomedical research and clinical applications, as these cells could be used …

We sought to obtain novel insights into schizophrenia pathogenesis by exploiting the
association between the disorder and chromosomal copy number (CNV) burden. We …

Reprogramming of adult human somatic cells to induced pluripotent stem cells (iPSCs) is a
novel approach to produce patient-specific cells for autologous transplantation. Whether …

Degeneration of medium spiny GABA neurons in the basal ganglia underlies motor
dysfunction in Huntington's disease (HD), which presently lacks effective therapy. In this …