Neuroblastoma (NB) is a pediatric tumor that originates from neural crest-derived cells
undergoing a defective differentiation due to genomic and epigenetic impairments …

Epigenetic dysregulation is increasingly appreciated as a hallmark of cancer, including
disease initiation, maintenance and therapy resistance. As a result, there have been …

Aberrant expression of MYC transcription factor family members predicts poor clinical
outcome in many human cancers. Oncogenic MYC profoundly alters metabolism and …

Neuroblastoma is a pediatric tumor of the developing sympathetic nervous system.
However, the cellular origin of neuroblastoma has yet to be defined. Here we studied the …

Gene expression is regulated by promoters and enhancers marked by histone H3 lysine 27
acetylation (H3K27ac), which is established by the paralogous histone acetyltransferases …

Immunotherapy with anti-GD2 antibodies has advanced the treatment of children with high-
risk neuroblastoma, but nearly half of patients relapse, and little is known about mechanisms …

Noradrenergic and mesenchymal identities have been characterized in neuroblastoma cell
lines according to their epigenetic landscapes and core regulatory circuitries. However, their …

Abstract Purpose of Review The evolving information of the initiation, tumor cell
heterogeneity, and plasticity of childhood neuroblastoma has opened up new perspectives …

Neuroblastoma is a solid, neuroendocrine tumor with divergent clinical behavior ranging
from asymptomatic to fatal. The diverse clinical presentations of neuroblastoma are directly …

The pediatric extra-cranial tumor neuroblastoma displays a low mutational burden while
recurrent copy number alterations are present in most high-risk cases. Here, we identify …