Although adenocarcinoma (ADC) is the most frequent lung cancer, its diagnosis is often late,
when the local invasion is important and/or the metastases have already appeared …

Rationale: Endobronchial ultrasound and transbronchial needle aspiration (EBUS-TBNA)
are commonly used for the diagnosis and mediastinal staging of lung cancer. Molecular …

Background Because most lung cancers are diagnosed at advanced stages, we are forced
to conduct molecular testing using small biopsy samples. Endobronchial ultrasound …

BACKGROUND Experts and scientific society guidelines recommend that rapid on-site
evaluation (ROSE) be used with endobronchial ultrasound-guided transbronchial needle …

The advent of targeted therapy in lung cancer has heralded a paradigm shift in the practice
of cytopathology with the need for accurately subtyping lung carcinoma, as well as providing …

With increasing requests for the evaluation of prognostic and predictive molecular
biomarkers, great attention must be paid to the preanalytical issues regarding sample quality …

BACKGROUND The detection of mutated epidermal growth factor receptor (EGFR) in non–
small cell lung cancer (NSCLC) with residual cell pellets derived from liquid‐based cytology …

Background Cytology smears are commonly collected during endobronchial ultrasound–
guided transbronchial needle aspiration (EBUS TBNA) procedures but are rarely used for …

The current standard of care for advanced non-small-cell lung cancer is based on detecting
actionable mutations that can benefit from targeted therapy. Comprehensive genetic tests …

Highlights•Morphologic and molecular subtyping of non-small cell lung carcinoma, which
must often be performed on cytologic or small histologic biopsy specimens, is necessary for …