The biology of TREM receptors

M Colonna - Nature Reviews Immunology, 2023 - nature.com
Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-
surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages …

The characteristics and pivotal roles of triggering receptor expressed on myeloid cells-1 in autoimmune diseases

S Gao, Y Yi, G Xia, C Yu, C Ye, F Tu, L Shen… - Autoimmunity …, 2019 - Elsevier
Triggering receptor expressed on myeloid cells-1 (TREM-1) engagement can directly trigger
inflammation or amplify an inflammatory response by synergizing with TLRs or NLRs …

sTREM-1 promotes the phagocytic function of microglia to induce hippocampus damage via the PI3K–AKT signaling pathway

L Lu, X Liu, J Fu, J Liang, Y Hou, H Dou - Scientific Reports, 2022 - nature.com
Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is a soluble form of
TREM-1 released during inflammation. Elevated sTREM-1 levels have been found in …

Serum sTREM-1 in adult-onset Still's disease: a novel biomarker of disease activity and a potential predictor of the chronic course

Z Wang, H Chi, Y Sun, J Teng, T Feng, H Liu… - …, 2020 - academic.oup.com
Objectives Triggering receptor expressed on myeloid cells-1 (TREM-1) is an amplifier of
inflammatory signals. Recently, a soluble form of TREM-1 (sTREM-1) was described. This …

[HTML][HTML] Expression of T helper 17 cells and interleukin 17 in lupus nephritis patients

NZ Saber, SH Maroof, DA Soliman, MS Fathi - The Egyptian …, 2017 - Elsevier
Background Modern data suggest that interleukin 17 (Il-17) and Il-17 producing cells play an
important role in the pathogenesis of lupus nephritis (LN). It was reported that T helper 17 …

Agomir miRNA-150-5p alleviates pristane-induced lupus by suppressing myeloid dendritic cells activation and inflammation via TREM-1 axis

C Yue, W Wang, S Gao, J Ye, T Zhang, Z Xing… - Inflammation …, 2023 - Springer
Objective Triggering receptors expressed on myeloid cells-1 (TREM-1) has been shown to
participate in inflammatory autoimmune diseases. Nevertheless, the detailed underlying …

Decreased expression of semaphorin 3A and semaphorin 7A levels and its association with systemic lupus erythematosus

P Wang, YM Mao, LN Liu, CN Zhao… - Immunological …, 2020 - Taylor & Francis
ABSTRACT A growing body of data suggests that semaphorins are involved in both normal
and pathological immune responses, as well as autoimmune pathologies. To investigate the …

Elevated plasma level of soluble triggering receptor expressed on myeloid cells-1 is associated with inflammation activity and is a potential biomarker of thrombosis in …

Y Edel, V Kliminski, E Pokroy-Shapira, S Oren… - Arthritis research & …, 2019 - Springer
Background Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is an
innate-immune receptor found in blood. Its presence reflects innate immune cell activation …

Soluble triggering receptor expressed on myeloid cell-1 reflects the cross-sectional activity of microscopic polyangiitis and granulomatosis with polyangiitis

T Yoon, JW Ha, JY Pyo, JJ Song, YB Park, SS Ahn… - Heliyon, 2023 - cell.com
Objectives We investigated whether soluble triggering receptor expressed on myeloid cells-
1 (sTREM-1) reflects cross-sectional activity of microscopic polyangiitis (MPA) and …

Plasma concentrations of sTREM-1 as markers for systemic adverse reactions in subjects treated with weekly rifapentine and isoniazid for latent tuberculosis infection

TY Wang, JY Feng, CC Shu, SS Lee, CY Chen… - Frontiers in …, 2022 - frontiersin.org
Background A regimen of once-weekly rifapentine plus isoniazid for 3 months (3HP) is an
effective treatment for subjects with latent tuberculosis infection; however, no reliable …