Background. Cholinesterases are a group of serine hydrolases that split the neurotransmitter
acetylcholine (ACh) and terminate its action. Of the two types, butyrylcholinesterase and …

Butyrylcholinesterase is a promiscuous enzyme that displays complex kinetic behavior. It is
toxicologically important because it detoxifies organophosphorus poisons (OP) by making a …

Differences in esterase expression among human, rhesus monkey, cynomolgus monkey,
dog, minipig, rabbit, rat, and mouse plasma were identified using native polyacrylamide gel …

Abstract Acetylcholinesterase (AChE, EC 3.1. 1.7) and butyrylcholinesterase (BChE, EC 3.1.
1.8) are related enzymes found across the animal kingdom. The critical role of …

While acetylcholinesterase (EC 3.1. 1.7) has a clearly defined role in neurotransmission, the
functions of its sister enzyme butyrylcholinesterase (EC 3.1. 1.8) are more obscure …

Successive rational mutations of human butyrylcholinesterase (BChE) followed by fusion to
human serum albumin have yielded an efficient hydrolase that offers realistic options for …

Acetylcholinesterase reactivators are crucial antidotes for the treatment of organophosphate
intoxication. Among the organophosphates, with the exception of soman, tabun (GA) …

The widespread use of organophosphorus compounds (OPs) as pesticides and the frequent
misuse of OP nerve agents in military conflicts or terrorist attacks emphasize the high clinical …

The high-density lipoprotein-associated enzyme paraoxonase 1 (PON1) hydrolyzes
lactones, aromatic esters, and neurotoxic organophosphorus (OP) compounds, including …

Protection from the toxicity of nerve agents is achieved by pretreatment with human
butyrylcholinesterase (BChE). Current methods for purifying large quantities of BChE from …