Telomeres, the ends of linear eukaryotic chromosomes, are characterized by the presence
of multiple repeats of a short DNA sequence. This telomeric DNA is protected from illicit …

Ku is an abundant, highly conserved DNA binding protein found in both prokaryotes and
eukaryotes that plays essential roles in the maintenance of genome integrity. In eukaryotes …

The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …

Telomerase is the enzyme responsible for maintenance of the length of telomeres by
addition of guanine-rich repetitive sequences. Telomerase activity is exhibited in gametes …

Telomerase is the ribonucleoprotein enzyme that catalyzes the extension of telomeric DNA
in eukaryotes. Recent work has begun to reveal key aspects of the assembly of the human …

Exchange of macromolecules between the nucleus and cytoplasm is a key regulatory event
in the expression of a cell's genome. This exchange requires a dedicated transport …

Mutations in the human telomerase RNA component (hTR), the telomerase
ribonucleoprotein component dyskerin (DKC1) and the poly (A) RNase (PARN) can lead to …

Telomeres are the physical ends of eukaryotic linear chromosomes. Telomeres form special
structures that cap chromosome ends to prevent degradation by nucleolytic attack and to …

Telomerase adds simple-sequence repeats to the ends of linear chromosomes to counteract
the loss of end sequence inherent in conventional DNA replication. Catalytic activity for …

Telomeres are the physical ends of eukaryotic chromosomes. They protect chromosome
ends from DNA degradation, recombination, and DNA end fusions, and they are important …