Langerhans cells (LCs) reside in the epidermis as a dense network of immune system
sentinels. These cells determine the appropriate adaptive immune response (inflammation …

Human papillomavirus (HPV) infection is a causative factor for various cancers of the
anogenital region and oropharynx, and is supposed to play an important cofactor role for …

Dendritic cells (DCs), monocytes, and macrophages are a heterogeneous population of
mononuclear phagocytes that are involved in antigen processing and presentation to initiate …

Dendritic cells (DCs) are sentinel immune cells that form a critical bridge linking the innate
and adaptive immune systems. Extensive research addressing the cellular origin and …

Macrophages are important for tissue development, homeostasis as well as immune
response upon injury or infection. For a long time they were only seen as one uniform group …

The skin is the body's largest organ. It serves as a barrier to pathogen entry and the first site
of immune defense. In the event of a skin injury, a cascade of events including inflammation …

Dendritic cells (DCs) are specialized immune sentinels that play key role in maintaining
immune homeostasis by efficiently regulating the delicate balance between protective …

Dendritic cells (DCs) are professional antigen presenting cells that constantly survey the
environment acting as sentinels of the immune system, including in the CNS. DCs are …

A detailed appreciation of the development, structure and function of human skin is
fundamental to understanding diseases that originate in or target the skin. Recent advances …

The ontogeny of human Langerhans cells (LCs) remains poorly characterized, in particular
the nature of LC precursors and the factors that may drive LC differentiation. Here we report …