Challenges of phototherapy for neonatal hyperbilirubinemia

J Wang, G Guo, A Li, WQ Cai… - Experimental and …, 2021 - spandidos-publications.com
Phototherapy is universally recognized as the first option for treating neonatal jaundice due
to its unparalleled efficiency and safety in reducing the high serum free bilirubin levels and …

Systemic regulation of bilirubin homeostasis: potential benefits of hyperbilirubinemia

R Fujiwara, M Haag, E Schaeffeler, AT Nies… - Hepatology, 2018 - journals.lww.com
Abstract von Willebrand Factor (vWF) was found to mediate platelet influx during the early
phase of liver regeneration in mice. Furthermore, increased vWF‐antigen (vWF‐Ag) levels …

Melatonin restores neutrophil functions and prevents apoptosis amid dysfunctional glutathione redox system

SK NaveenKumar, M Hemshekhar… - Journal of pineal …, 2020 - Wiley Online Library
Melatonin is a chronobiotic hormone, which can regulate human diseases like cancer,
atherosclerosis, respiratory disorders, and microbial infections by regulating redox system …

[HTML][HTML] Hemin-induced platelet activation and ferroptosis is mediated through ROS-driven proteasomal activity and inflammasome activation: Protection by Melatonin

SK NaveenKumar, M Hemshekhar, K Kemparaju… - … Et Biophysica Acta (BBA …, 2019 - Elsevier
Reactive oxygen species (ROS) are capable of inducing cell death or apoptosis. Recently,
we demonstrated that lipid-ROS can mediate ferroptosis and activation of human platelets …

The role of reactive oxygen species and ferroptosis in heme-mediated activation of human platelets

SK NaveenKumar, BN SharathBabu… - ACS chemical …, 2018 - ACS Publications
Hemolysis, a process by which the destruction of red blood cells leads to the release of
hemoglobin, is a critical event observed during hemolytic disorders. Under oxidative stress …

Targetting ferroptosis for blood cell-related diseases

Z Chen, J Jiang, N Fu, L Chen - Journal of Drug Targeting, 2022 - Taylor & Francis
Ferroptosis is an iron-dependent cell death pathway and participates in various diseases.
Current evidence suggests that ferroptosis can obviously affect the function of blood cells …

Endogenous toxic metabolites and implications in cancer therapy

N Lee, ME Spears, AE Carlisle, D Kim - Oncogene, 2020 - nature.com
It is well recognized that many metabolic enzymes play essential roles in cancer cells in
producing building blocks such as nucleotides, which are required in greater amounts due …

Hemolysis during pediatric extracorporeal membrane oxygenation: associations with circuitry, complications, and mortality

HJ Dalton, K Cashen, RW Reeder… - Pediatric Critical Care …, 2018 - journals.lww.com
Objectives: To describe factors associated with hemolysis during pediatric extracorporeal
membrane oxygenation and the relationships between hemolysis, complications, and …

Development and validation of a prediction model for the early occurrence of acute kidney injury in patients with acute pancreatitis

S Wu, Q Zhou, Y Cai, X Duan - Renal failure, 2023 - Taylor & Francis
Background Acute pancreatitis (AP) is associated with a high incidence of acute kidney
injury (AKI). This study aimed to develop a nomogram for predicting the early onset of AKI in …

Bilirubin acts as a multipotent guardian of cardiovascular integrity: more than just a radical idea

AC Bulmer, B Bakrania, EF Du Toit… - American Journal …, 2018 - journals.physiology.org
Bilirubin, a potentially toxic catabolite of heme and indicator of hepatobiliary insufficiency,
exhibits potent cardiac and vascular protective properties. Individuals with Gilbert's …