Genetic factors strongly affect susceptibility to common diseases and also influence disease-
related quantitative traits. Identifying the relevant genes has been difficult, in part because …

Assessing the association between DNA variants and disease has been used widely to
identify regions of the genome and candidate genes that contribute to disease. However …

Crohn's disease, and ulcerative colitis, the two main types of chronic inflammatory bowel
disease, are multifactorial conditions of unknown aetiology. A susceptibility locus for Crohn's …

Crohn's disease is a chronic inflammatory disorder of the gastrointestinal tract, which is
thought to result from the effect of environmental factors in a genetically predisposed host. A …

Autism spectrum disorders (ASDs) represent a group of childhood neurodevelopmental and
neuropsychiatric disorders characterized by deficits in verbal communication, impairment of …

Motivation: Polymorphisms in human genes are being described in remarkable numbers.
Determining which polymorphisms and which environmental factors are associated with …

Previous studies have narrowed the interval containing PSORS1, the psoriasis-susceptibility
locus in the major histocompatibility complex (MHC), to an∼ 300-kb region containing HLA …

Systemic lupus erythematosus (SLE, OMIM 152700) is a complex autoimmune disease that
affects 0.05% of the Western population, predominantly women 1, 2, 3, 4. A number of …

A genome-wide association study was performed to identify genetic factors involved in
susceptibility to psoriasis (PS) and psoriatic arthritis (PSA), inflammatory diseases of the skin …

Background Autoimmune and autoinflammatory diseases involve interactions between
genetic risk factors and environmental triggers. We searched for a gene on chromosome …