Obesity‐related hypertension: Pathogenesis, cardiovascular risk, and treatment—A position paper of the The Obesity Society and the American Society of …
In light of the worldwide epidemic of obesity, and in recognition of hypertension as a major
factor in the cardiovascular morbidity and mortality associated with obesity, The Obesity …
factor in the cardiovascular morbidity and mortality associated with obesity, The Obesity …
[HTML][HTML] Molecular genetics of human obesity: A comprehensive review
Obesity and its related health complications is a major problem worldwide. Hypothalamus
and their signalling molecules play a critical role in the intervening and coordination with …
and their signalling molecules play a critical role in the intervening and coordination with …
The human and mouse enteric nervous system at single-cell resolution
E Drokhlyansky, CS Smillie, N Van Wittenberghe… - Cell, 2020 - cell.com
The enteric nervous system (ENS) coordinates diverse functions in the intestine but has
eluded comprehensive molecular characterization because of the rarity and diversity of …
eluded comprehensive molecular characterization because of the rarity and diversity of …
A neural basis for melanocortin-4 receptor–regulated appetite
Abstract Pro-opiomelanocortin (POMC)-and agouti-related peptide (AgRP)-expressing
neurons of the arcuate nucleus of the hypothalamus (ARC) are oppositely regulated by …
neurons of the arcuate nucleus of the hypothalamus (ARC) are oppositely regulated by …
Melanocortin-4 receptor–regulated energy homeostasis
MJ Krashes, BB Lowell, AS Garfield - Nature neuroscience, 2016 - nature.com
The melanocortin system provides a conceptual blueprint for the central control of energetic
state. Defined by four principal molecular components—two antagonistically acting ligands …
state. Defined by four principal molecular components—two antagonistically acting ligands …
The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology
YX Tao - Endocrine reviews, 2010 - academic.oup.com
Abstract The melanocortin-4 receptor (MC4R) was cloned in 1993 by degenerate PCR;
however, its function was unknown. Subsequent studies suggest that the MC4R might be …
however, its function was unknown. Subsequent studies suggest that the MC4R might be …
Nicotine decreases food intake through activation of POMC neurons
Smoking decreases appetite, and smokers often report that they smoke to control their
weight. Understanding the neurobiological mechanisms underlying the anorexic effects of …
weight. Understanding the neurobiological mechanisms underlying the anorexic effects of …
[HTML][HTML] Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance
Macroautophagy is a lysosomal degradative pathway that maintains cellular homeostasis by
turning over cellular components. Here we demonstrate a role for autophagy in …
turning over cellular components. Here we demonstrate a role for autophagy in …
Bacterial ClpB heat-shock protein, an antigen-mimetic of the anorexigenic peptide α-MSH, at the origin of eating disorders
N Tennoune, P Chan, J Breton, R Legrand… - Translational …, 2014 - nature.com
The molecular mechanisms at the origin of eating disorders (EDs), including anorexia
nervosa (AN), bulimia and binge-eating disorder (BED), are currently unknown. Previous …
nervosa (AN), bulimia and binge-eating disorder (BED), are currently unknown. Previous …
[HTML][HTML] Defining a novel leptin–melanocortin–kisspeptin pathway involved in the metabolic control of puberty
Objective Puberty is a key developmental phenomenon highly sensitive to metabolic
modulation. Worrying trends of changes in the timing of puberty have been reported in …
modulation. Worrying trends of changes in the timing of puberty have been reported in …