The CB1 cannabinoid receptor is a G-protein coupled receptor highly expressed throughout
the central nervous system that is a promising target for the treatment of various disorders …

Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors
including PPARα, PPARγ, and PPARβ/δ, acting as transcription factors to regulate the …

Endocannabinoid signalling is considered one of the most important modulatory systems in
a whole organism. Research has yielded great insight on the mechanisms that link …

Cannabinoids (CBs) are used to treat chronic pain, chemotherapy-induced nausea and
vomiting, and multiple sclerosis spasticity. Recently, the medicinal use of CBs has attracted …

Obesity-mediated metabolic syndrome remains the leading cause of death worldwide.
Among many potential targets for pharmacological intervention, a promising strategy …

The cannabinoid 1 (CB1) receptor regulates appetite and body weight; however, unwanted
central side effects of both agonists (in wasting disorders) or antagonists (in obesity and …

Abstract Originating from Eastern Asia, the plant Cannabis sativa has been used for
centuries as a medicinal treatment. The unwanted psychotropic effects of one of its major …

Non-alcoholic fatty liver disease (NAFLD) presents a pervasive global pandemic, affecting
approximately 25% of the world's population. This grave health issue not only demands …

Cannabinoids have shown to exert their therapeutic actions through a variety of targets.
These include not only the canonical cannabinoid receptors CB1R and CB2R but also …

Over-activation of the endocannabinoid/CB 1 R system is a hallmark feature of obesity and
its related comorbidities, most notably type 2 diabetes (T2D), and non-alcoholic fatty liver …