Chromogranins/secretogranins or granins are a class of acidic, secretory proteins that occur
in endocrine, neuroendocrine, and neuronal cells. Granins are the precursors of several …

The use of unconventional model organisms is significantly increasing in different fields of
research, widely contributing to advance life sciences understanding. Among fishes, the …

Abstract Aims High chromogranin-A (CgA) levels were observed in patients with heart failure
but its source remained uncertain. We evaluated whether CgA is produced by myocardium …

Chromogranin A (CgA (CHGA)) is the major soluble protein co-stored and co-released with
catecholamines and can function as a pro-hormone by giving rise to several bioactive …

Circulating levels of catestatin (Cts; human chromogranin A352–372) decrease in the
plasma of patients with essential hypertension. Genetic ablation of the chromogranin A …

The catecholamine release-inhibitory catestatin [Cts; human chromogranin (Cg) A352-372,
bovine CgA344-364] is a vasoreactive and anti-hypertensive peptide derived from CgA …

In the past 50 years, extensive evidence has shown the ability of vertebrate cardiac non-
neuronal cells to synthesize and release catecholamines (CA). This formed the mindset …

A range of inflammatory conditions is associated with pathologically high levels of circulating
chromogranin A (CgA). This prohormone belongs to the family of uniquely acidic proteins co …

Aims Catestatin (CST) is a chromogranin A (CgA)-derived peptide (hCgA352–372) with
three identified human variants (G364S/P370L/R374Q-CST) that show differential potencies …

In this study we tested the hypothesis that vasostatins could act as myocardial modulators in
the mammalian heart. Using the Langendorff–perfused rat heart, the cardiac effects of the …