Abstract The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …

The molecular mechanisms of cellular insulin action have been the focus of much
investigation since the discovery of the hormone 100 years ago. Insulin action is impaired in …

Many cellular processes in cancer are attributed to kinase signaling networks. V-akt murine
thymoma viral oncogene homolog (AKT) plays a major role in the PI3K/AKT signaling …

Akt is a serine/threonine kinase and it participates in the key role of the PI3K signaling
pathway. The Akt can be activated by a wide range of growth signals and the biochemical …

Paclitaxel is a well-known anticancer agent with a unique mechanism of action. It is
considered to be one of the most successful natural anticancer drugs available. This study …

Abstract The phosphatidylinositol 3-kinase (PI3K)-Akt and the mammalian target of
rapamycin (mTOR) represent two vital intracellular signaling pathways, which are …

Glioblastoma (GBM) is a devastating type of brain tumor, and current therapeutic treatments,
including surgery, chemotherapy, and radiation, are palliative at best. The design of effective …

Background The four major RNA adenosine modifications, ie, m 6 A, m 1 A, alternative
polyadenylation, and adenosine-to-inosine RNA editing, are mediated mostly by the “writer” …

The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide
gene. Achieving the same using small molecules would have a tremendous impact on …

Curcumin as a hydrophobic polyphenol is extracted from the rhizome of Curcuma longa.
Curcumin is widely used as a dietary spice and a topical medication for the treatment of …