Mechanisms of pathogenicity for the emerging fungus Candida auris

MV Horton, AM Holt, JE Nett - Plos Pathogens, 2023 - journals.plos.org
Candida auris recently emerged as an urgent public health threat, causing outbreaks of
invasive infections in healthcare settings throughout the world. This fungal pathogen persists …

The emerging role of extracellular vesicles in fungi: A double-edged sword

Y Lai, B Jiang, F Hou, X Huang, B Ling, H Lu… - Frontiers in …, 2023 - frontiersin.org
Fungi are eukaryotic microorganisms found in nature, which can invade the human body
and cause tissue damage, inflammatory reactions, organ dysfunctions, and diseases. These …

Candida albicans extracellular vesicles trigger type I IFN signalling via cGAS and STING

H Brown Harding, GN Kwaku, CM Reardon… - Nature …, 2024 - nature.com
The host type I interferon (IFN) pathway is a major signature of inflammation induced by the
human fungal pathogen, Candida albicans. However, the molecular mechanism for …

Pathogenicity & virulence of Histoplasma capsulatum - A multifaceted organism adapted to intracellular environments

AF Valdez, DZ Miranda, AJ Guimarães, L Nimrichter… - Virulence, 2022 - Taylor & Francis
Histoplasmosis is a systemic mycosis caused by the thermally dimorphic fungus
Histoplasma capsulatum. Although healthy individuals can develop histoplasmosis, the …

Inhibitory Effects of the Fungal Pigment Rubiginosin C on Hyphal and Biofilm Formation in Candida albicans and Candida auris

H Zeng, M Stadler, WR Abraham, M Müsken, H Schrey - Journal of Fungi, 2023 - mdpi.com
The two fungal human pathogens, Candida auris and Candida albicans, possess a variety
of virulence mechanisms. Among them are the formation of biofilms to protect yeast against …

Inhibitory effects of a maleimide compound on the virulence factors of Candida albicans

Y Li, C Chen, L Cong, S Mao, M Shan, Z Han, J Mao… - Virulence, 2023 - Taylor & Francis
Candidiasis caused by Candida albicans infection has long been a serious human health
problem. The pathogenicity of C. albicans is mainly due to its virulence factors, which are …

Absence of farnesol salvage in Candida albicans and probably in other fungi

A Voshall, DJ Gutzmann, IB Verdaguer… - Applied and …, 2024 - journals.asm.org
Farnesol salvage, a two-step pathway converting farnesol to farnesyl pyrophosphate (FPP),
occurs in bacteria, plants, and animals. This paper investigates the presence of this pathway …

The evil companion of OSCC: Candida albicans

Z Yang, S Zhang, N Ji, J Li, Q Chen - Oral Diseases, 2024 - Wiley Online Library
Objective Microbial dysbiosis and microbiome‐induced inflammation may play a role in the
etiopathogenesis of oral squamous cell carcinoma (OSCC). Candida albicans (C. albicans) …

Extracellular vesicles of Candida albicans regulate its own growth through the l-arginine/nitric oxide pathway

Y Wei, Z Wang, Y Liu, B Liao, Y Zong, Y Shi… - Applied Microbiology …, 2023 - Springer
Candida albicans is the main conditional pathogenic fungus among the human microbiome.
Extracellular vesicles (EVs) secreted by C. albicans are important for its pathogenesis …

Strategies to Promote the Journey of Nanoparticles Against Biofilm‐Associated Infections

X Wang, D Wang, H Lu, X Wang, X Wang, J Su, G Xia - Small, 2024 - Wiley Online Library
Biofilm‐associated infections are one of the most challenging healthcare threats for humans,
accounting for 80% of bacterial infections, leading to persistent and chronic infections. The …