Cysteine cathepsins are highly upregulated in a wide variety of cancers by mechanisms
ranging from gene amplification to post-transcriptional modification. Their localization within …

Introduction: Cathepsin B is of significant importance to cancer therapy as it is involved in
various pathologies and oncogenic processes in humans. Numerous studies have shown …

The invasive nature of brain-tumour cells makes an important contribution to the
ineffectiveness of current treatment modalities, as the remaining tumour cells inevitably …

Proteases play causal roles in the malignant progression of human tumors. This review
centers on the roles in this process of cysteine cathepsins, ie, peptidases belonging to the …

Summary¶ Local invasion of tumour cells is characteristic of brain tumour progression. It is
associated with increased motility and a potential to hydrolyse macromolecular components …

Background Several studies have found that Cathepsin B (CTSB) is up-regulated in many
tumor types and facilitates tumor progression. However, the role of CTSB in hepatocellular …

Cathepsin B is a papain-family cysteine protease that is normally located in lysosomes,
where it is involved in the turnover of proteins and plays various roles in maintaining the …

Angiogenesis, the process by which new branches sprout from existing vessels, requires the
degradation of the vascular basement membrane and remodeling of the ECM in order to …

Early local invasion by astrocytoma cells results in tumor recurrence even after apparent
total surgical resection, leading to the poor prognosis associated with malignant …

Objective The lysosomal protease cathepsin B is upregulated in human pancreatic ductal
adenocarcinoma (PDA) and represents a potential therapeutic target. Loss of cathepsin B …