When the microbiome shapes the host: immune evolution implications for infectious disease

MA Hanson - … Transactions of the Royal Society B, 2024 - royalsocietypublishing.org
The microbiome includes both 'mutualist'and 'pathogen'microbes, regulated by the same
innate immune architecture. A major question has therefore been: how do hosts prevent …

Invasive fungal infections and oomycoses in cats: 1. Diagnostic approach

VR Barrs, PM Bęczkowski, JJ Talbot… - Journal of Feline …, 2024 - journals.sagepub.com
Clinical relevance: In contrast to superficial fungal infections, such as dermatophytosis,
invasive fungal infections (IFIs) are characterised by penetration of tissues by fungal …

Ecology-relevant bacteria drive the evolution of host antimicrobial peptides in Drosophila

MA Hanson, L Grollmus, B Lemaitre - Science, 2023 - science.org
Antimicrobial peptides are host-encoded immune effectors that combat pathogens and
shape the microbiome in plants and animals. However, little is known about how the host …

Toward telomere-to-telomere cat genomes for precision medicine and conservation biology

WJ Murphy, AJ Harris - Genome Research, 2024 - genome.cshlp.org
Genomic data from species of the cat family Felidae promise to stimulate veterinary and
human medical advances, and clarify the coherence of genome organization. We describe …

[HTML][HTML] A single amino acid polymorphism in natural Metchnikowin alleles of Drosophila results in systemic immunity and life history tradeoffs

JI Perlmutter, JR Chapman, MC Wilkinson… - Plos …, 2024 - journals.plos.org
Antimicrobial peptides (AMPs) are at the interface of interactions between hosts and
microbes and are therefore expected to be rapidly evolving in a coevolutionary arms race …

[HTML][HTML] Host defence peptide LEAP2 contributes to antimicrobial activity in a mustache toad (Leptobrachium liui)

J Chen, CY Zhang, JY Chen, RWX Seah… - BMC Veterinary …, 2023 - Springer
Background The liver-expressed antimicrobial peptide 2 (LEAP2) is essential in host
immunity against harmful pathogens and is only known to act as an extracellular modulator …

In vitro virulotyping, antifungal susceptibility testing and DNA fingerprinting of Microsporum canis strains of canine and feline origin

JK Bagra, SS Nair, V Athira, MS Kumar… - … and Infectious Diseases, 2024 - Elsevier
Microsporum canis is considered the common dermatophyte agent associated with
ringworm in felines and canines. In the present study, we sampled n= 548 felines and …

Single innate immune effectors control ecological microbiome bacteria across evolutionary timescales

MA Hanson, L Grollmus, B Lemaitre - bioRxiv, 2022 - biorxiv.org
Antimicrobial peptides are host-encoded antibiotics that combat invading microbes and help
shape the microbiome in plants and animals. However, little is known about how the host …