Metformin for cardiovascular protection, inflammatory bowel disease, osteoporosis, periodontitis, polycystic ovarian syndrome, neurodegeneration, cancer …

M Ala, M Ala - ACS pharmacology & translational science, 2021 - ACS Publications
Diabetes is accompanied by several complications. Higher prevalence of cancers,
cardiovascular diseases, chronic kidney disease (CKD), obesity, osteoporosis, and …

Hyperandrogenism and Polycystic ovary syndrome: Effects in pregnancy and offspring development

GA Abruzzese, AF Silva, ME Velazquez… - WIREs mechanisms …, 2022 - Wiley Online Library
Polycystic ovary syndrome (PCOS) is one of the major endocrine disorders affecting women
of reproductive age. Its etiology remains unclear. It is suggested that environmental factors …

Insight into TLR4 receptor inhibitory activity via QSAR for the treatment of Mycoplasma pneumonia disease

Z Zhu, Z Rahman, M Aamir, SZA Shah, S Hamid… - RSC …, 2023 - pubs.rsc.org
Mycoplasma pneumoniae (MP) is one of the most common pathogenic organisms causing
upper and lower respiratory tract infections, lung injury, and even death in young children …

Systemic and ovarian inflammation in women with polycystic ovary syndrome

Y Zhai, Y Pang - Journal of Reproductive Immunology, 2022 - Elsevier
Polycystic ovary syndrome (PCOS) is a common endocrine/reproductive/metabolic disorder.
The etiology of PCOS is complex and has been linked to low-grade chronic inflammation …

Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome‐Induced Pyroptosis via Inhibiting the TLR4/NF‐κB/PFKFB3 Signaling in …

Y Zhang, W Liu, Y Zhong, Q Li, M Wu… - Oxidative Medicine …, 2021 - Wiley Online Library
NOD‐like receptor family, pyrin domain‐containing protein 3 (NLRP3) inflammasome‐
mediated pyroptosis is a crucial event in the preeclamptic pathogenesis, tightly linked with …

Suppression of uterine and placental ferroptosis by N-acetylcysteine in a rat model of polycystic ovary syndrome

M Hu, Y Zhang, S Ma, J Li, X Wang… - Molecular human …, 2021 - academic.oup.com
The mechanisms that link hyperandrogenism and insulin (INS) resistance (HAIR) to the
increased miscarriage rate in women with polycystic ovary syndrome (PCOS) remain …

The abnormal level of HSP70 is related to Treg/Th17 imbalance in PCOS patients

Y Yang, J Xia, Z Yang, G Wu, J Yang - Journal of Ovarian Research, 2021 - Springer
Background Polycystic ovary syndrome (PCOS) is a disease with chronic nonspecific low-
grade inflammation. The imbalance of immune cells exists in PCOS. Several studies have …

Transcriptomic screening to identify hub genes and drug signatures for PCOS based on RNA-Seq data in granulosa cells

M Zanjirband, M Baharlooie, Z Safaeinejad… - Computers in Biology …, 2023 - Elsevier
Background Polycystic ovary syndrome (PCOS) is one of the most incident reproductive
diseases, and remains the main cause of female infertility. Granulosa cells play a critical role …

Dysregulation of immune response in PCOS organ system

J Wang, T Yin, S Liu - Frontiers in immunology, 2023 - frontiersin.org
Polycystic ovary syndrome (PCOS) is the most common reproductive endocrine disorder
affecting women, which can lead to infertility. Infertility, obesity, hirsutism, acne, and irregular …

Increased uterine androgen receptor protein abundance results in implantation and mitochondrial defects in pregnant rats with hyperandrogenism and insulin …

Y Zhang, M Hu, F Yang, Y Zhang, S Ma… - Journal of Molecular …, 2021 - Springer
In this study, we show that during normal rat pregnancy, there is a gestational stage-
dependent decrease in androgen receptor (AR) abundance in the gravid uterus and that this …