Oxidative stress is a component of many diseases, including atherosclerosis, chronic
obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small …

An abundant metal in the human body, iron is essential for key biological pathways
including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound …

Myopia, also known as short-sightedness or near-sightedness, is a very common condition
that typically starts in childhood. Severe forms of myopia (pathologic myopia) are associated …

Approximately 30% of human lung cancers acquire mutations in either Keap1 or Nfe2l2,
resulting in the stabilization of Nrf2, the Nfe2l2 gene product, which controls oxidative …

Exposure to antioxidants and xenobiotics triggers the expression of a myriad of genes
encoding antioxidant proteins, detoxifying enzymes, and xenobiotic transporters to offer …

Ferroptosis is an iron-and lipid peroxidation-dependent cell death modality and emerging
evidence indicates that ferroptosis has great explanatory potential for neuronal loss and …

Although the gain of function (GOF) of p53 mutants is well recognized, it remains unclear
whether different p53 mutants share the same cofactors to induce GOFs. In a proteomic …

Iron is a transition metal that due to its inherent ability to exchange electrons with a variety of
molecules is essential to support life. In mammals, iron exists mostly in the form of heme …

Mitochondria are membrane-enclosed organelles with endosymbiotic origins, harboring
independent genomes and a unique biochemical reaction network. To perform their critical …

Ferroptosis is triggered by a chain of intracellular labile iron‐dependent peroxidation of cell
membrane phospholipids. Ferroptosis is important not only as a cause of ischaemic and …