[HTML][HTML] Clinical implications of targeting XPO1-mediated nuclear export in multiple myeloma

UH Gandhi, W Senapedis, E Baloglu, TJ Unger… - … Myeloma and Leukemia, 2018 - Elsevier
Multiple myeloma (MM) is a malignancy of plasma cells that is typically chronic, and relapse
is common. Current therapeutic strategies include combination and sequential treatments …

Targeting nuclear export proteins in multiple myeloma therapy

N Theodoropoulos, G Lancman, A Chari - Targeted oncology, 2020 - Springer
Multiple myeloma (MM) is an incurable malignancy of plasma cells with a clinical course
characterized by multiple relapses and treatment refractoriness. While recent treatment …

Targeting nuclear export proteins in multiple myeloma therapy

S Richard, S Jagannath - BioDrugs, 2022 - Springer
Nuclear export proteins such as exportin-1 (XPO1) transport tumor-suppressor proteins and
other growth-regulatory proteins from the nucleus to the cytoplasm. Overexpression of XPO1 …

Selinexor in multiple myeloma

EA Martino, E Vigna, A Bruzzese… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Selinexor, an XPO1 inhibitor, has emerged as a promising therapeutic option in
the challenging landscape of relapsed/refractory multiple myeloma (RRMM). Areas covered …

Treatment of multiple myeloma with selinexor: a review

Q Huang, R Zhao, L Xu, X Hao… - Therapeutic Advances in …, 2024 - journals.sagepub.com
Over the last 20 years, breakthroughs in accessible therapies for the treatment of multiple
myeloma (MM) have been made. Nevertheless, patients with MM resistant to …

[PDF][PDF] Selinexor in multiple myeloma

FM Labanca, E Lucia, V Olivito, A Zimbo - 2024 - researchgate.net
Introduction: Selinexor, an XPO1 inhibitor, has emerged as a promising therapeutic option in
the challenging landscape of relapsed/refractory multiple myeloma (RRMM). Areas covered …