The generation of induced pluripotent stem cells (iPSCs) from somatic cells demonstrated
that adult mammalian cells can be reprogrammed to a pluripotent state by the enforced …

The stable states of differentiated cells are now known to be controlled by dynamic
mechanisms that can easily be perturbed. An adult cell can therefore be reprogrammed …

The genome is partitioned into topologically associated domains and genomic
compartments with shared chromatin valence. This architecture is constrained by the DNA …

Pluripotent stem-cell lines can be obtained through the reprogramming of somatic cells from
different tissues and species by ectopic expression of defined factors. In theory, these cells …

Reprogramming of somatic cells to a pluripotent embryonic stem cell-like state has been
achieved by nuclear transplantation of a somatic nucleus into an enucleated egg and most …

Induced pluripotent stem cells (iPSCs) have been generated by enforced expression of
defined sets of transcription factors in somatic cells. It remains controversial whether iPSCs …

Pluripotent cells can be derived from fibroblasts by ectopic expression of defined
transcription factors. A fundamental unresolved question is whether terminally differentiated …

Odor signals received by odorant receptors (ORs) expressed by olfactory sensory neurons
(OSNs) in the olfactory epithelium (OE) are represented as an odor map in the olfactory bulb …

Much work has been published on the cis-regulatory elements that affect gene function
locally, as well as on the biochemistry of the transcription factors and chromatin-and histone …

Therapeutic cloning, whereby somatic cell nuclear transfer (SCNT) is used to generate
patient-specific embryonic stem cells (ESCs) from blastocysts cloned by nuclear transfer …