Microtubule-based transport and the distribution, tethering, and organization of organelles
K Barlan, VI Gelfand - Cold Spring Harbor perspectives …, 2017 - cshperspectives.cshlp.org
Microtubules provide long tracks along which a broad range of organelles and vesicles are
transported by kinesin and dynein motors. Motor protein complexes also tether cargoes to …
transported by kinesin and dynein motors. Motor protein complexes also tether cargoes to …
WNT signaling in neuronal maturation and synaptogenesis
SB Rosso, NC Inestrosa - Frontiers in cellular neuroscience, 2013 - frontiersin.org
The Wnt signaling pathway plays a role in the development of the central nervous system
and growing evidence indicates that Wnts also regulates the structure and function of the …
and growing evidence indicates that Wnts also regulates the structure and function of the …
Soluble forms of tau are toxic in Alzheimer's disease
K Kopeikina, B Hyman, T Spires-Jones - Translational neuroscience, 2012 - degruyter.com
Accumulation of neurofibrillary tangles (NFT), intracellular inclusions of fibrillar forms of tau,
is a hallmark of Alzheimer's disease. NFT have been considered causative of neuronal …
is a hallmark of Alzheimer's disease. NFT have been considered causative of neuronal …
[HTML][HTML] Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain
KJ Kopeikina, GA Carlson, R Pitstick… - The American journal of …, 2011 - Elsevier
Neurofibrillary tangles (NFT), intracellular inclusions of abnormal fibrillar forms of
microtubule associated protein tau, accumulate in Alzheimer's disease (AD) and other …
microtubule associated protein tau, accumulate in Alzheimer's disease (AD) and other …
Tau pathophysiology in neurodegeneration: a tangled issue
TL Spires-Jones, WH Stoothoff, A De Calignon… - Trends in …, 2009 - cell.com
Neurodegenerative tauopathies are marked by their common pathologic feature of
aggregates formed of hyperphosphorylated tau protein, which are associated with synapse …
aggregates formed of hyperphosphorylated tau protein, which are associated with synapse …
Single molecule imaging reveals differences in microtubule track selection between Kinesin motors
D Cai, DP McEwen, JR Martens, E Meyhofer… - PLoS …, 2009 - journals.plos.org
Cells generate diverse microtubule populations by polymerization of a common α/β-tubulin
building block. How microtubule associated proteins translate microtubule heterogeneity …
building block. How microtubule associated proteins translate microtubule heterogeneity …
Microtubule-severing enzymes at the cutting edge
DJ Sharp, JL Ross - Journal of cell science, 2012 - journals.biologists.com
ATP-dependent severing of microtubules was first reported in Xenopus laevis egg extracts in
1991. Two years later this observation led to the purification of the first known microtubule …
1991. Two years later this observation led to the purification of the first known microtubule …
The microtubule-severing proteins spastin and katanin participate differently in the formation of axonal branches
Neurons express two different microtubule-severing proteins, namely P60-katanin and
spastin. Here, we performed studies on cultured neurons to ascertain whether these two …
spastin. Here, we performed studies on cultured neurons to ascertain whether these two …
On and around microtubules: an overview
RH Wade - Molecular biotechnology, 2009 - Springer
Microtubules are hollow tubes some 25 nm in diameter participating in the eukaryotic
cytoskeleton. They are built from αβ-tubulin heterodimers that associate to form …
cytoskeleton. They are built from αβ-tubulin heterodimers that associate to form …
Tau protects microtubules in the axon from severing by katanin
Microtubules in the axon are more resistant to severing by katanin than microtubules
elsewhere in the neuron. We have hypothesized that this is because of the presence of tau …
elsewhere in the neuron. We have hypothesized that this is because of the presence of tau …