Microtubules provide long tracks along which a broad range of organelles and vesicles are
transported by kinesin and dynein motors. Motor protein complexes also tether cargoes to …

The Wnt signaling pathway plays a role in the development of the central nervous system
and growing evidence indicates that Wnts also regulates the structure and function of the …

Accumulation of neurofibrillary tangles (NFT), intracellular inclusions of fibrillar forms of tau,
is a hallmark of Alzheimer's disease. NFT have been considered causative of neuronal …

Neurofibrillary tangles (NFT), intracellular inclusions of abnormal fibrillar forms of
microtubule associated protein tau, accumulate in Alzheimer's disease (AD) and other …

Neurodegenerative tauopathies are marked by their common pathologic feature of
aggregates formed of hyperphosphorylated tau protein, which are associated with synapse …

Cells generate diverse microtubule populations by polymerization of a common α/β-tubulin
building block. How microtubule associated proteins translate microtubule heterogeneity …

ATP-dependent severing of microtubules was first reported in Xenopus laevis egg extracts in
1991. Two years later this observation led to the purification of the first known microtubule …

Neurons express two different microtubule-severing proteins, namely P60-katanin and
spastin. Here, we performed studies on cultured neurons to ascertain whether these two …

Microtubules are hollow tubes some 25 nm in diameter participating in the eukaryotic
cytoskeleton. They are built from αβ-tubulin heterodimers that associate to form …

Microtubules in the axon are more resistant to severing by katanin than microtubules
elsewhere in the neuron. We have hypothesized that this is because of the presence of tau …