Chromosomal instability (CIN) is a hallmark of human cancer, and it is associated with poor
prognosis, metastasis, and therapeutic resistance. CIN results from errors in chromosome …

The major innate immune cell types involved in tuberculosis (TB) infection are
macrophages, dendritic cells (DCs), neutrophils and natural killer (NK) cells. These immune …

Co-infection with Mycobacterium tuberculosis is the leading cause of death in individuals
infected with HIV-1. It has long been known that HIV-1 infection alters the course of M …

The genomic complexity of profound copy number aberrations has prevented effective
molecular stratification of ovarian cancers. Here, to decode this complexity, we derived copy …

Mycobacterium tuberculosis (Mtb) is the causative agent of human tuberculosis (TB) which
primarily infects the macrophages. Nearly a quarter of the world's population is infected …

The adoption of Warburg metabolism is critical for the activation of macrophages in
response to lipopolysaccharide. Macrophages stimulated with lipopolysaccharide increase …

T cell development in the thymus is essential for cellular immunity and depends on the
organotypic thymic epithelial microenvironment. In comparison with other organs, the size …

Monocytes and macrophages are innate immune cells with diverse functions ranging from
phagocytosis of microorganisms to forming a bridge with the adaptive immune system. A …

Background: Cardiac involvement is an important determinant of mortality among
sarcoidosis patients. Although granulomatous inflammation is a hallmark finding in cardiac …

DNA damage occurs on exposure to genotoxic agents and during physiological DNA
transactions. DNA double-strand breaks (DSBs) are particularly dangerous lesions that …