The Rise of Boron-Containing Compounds: Advancements in Synthesis, Medicinal Chemistry, and Emerging Pharmacology

RJ Grams, WL Santos, IR Scorei, A Abad-García… - Chemical …, 2024 - ACS Publications
Boron-containing compounds (BCC) have emerged as important pharmacophores. To date,
five BCC drugs (including boronic acids and boroles) have been approved by the FDA for …

Boron cluster compounds as new chemical leads for antimicrobial therapy

K Fink, M Uchman - Coordination Chemistry Reviews, 2021 - Elsevier
Boron cluster compounds are inorganic compounds with chemical compositions and
structures vastly different from those of organic compounds, albeit with the ability to form a …

Challenges and opportunities for the application of boron clusters in drug design

ZJ Lesnikowski - Journal of medicinal chemistry, 2016 - ACS Publications
There are two branches in boron medicinal chemistry: the first focuses on single boron atom
compounds, and the second utilizes boron clusters. Boron clusters and their heteroatom …

Boron science

NS Hosmane - New technologies and applications, 2011 - api.taylorfrancis.com
What is boron? The question itself may not seem very significant to many people. Their
introduction to the word “boron” could come as the butt of a joke. Conan O'Brien made jokes …

Boron in drug discovery: carboranes as unique pharmacophores in biologically active compounds

F Issa, M Kassiou, LM Rendina - Chemical reviews, 2011 - ACS Publications
Boron, in the form of boric acid, has played a role in medicine as a mild antiseptic and an
eye wash since its preparation from borax in the 18th century. However, the use of boron in …

Boron containing compounds as protease inhibitors

R Smoum, A Rubinstein, VM Dembitsky… - Chemical …, 2012 - ACS Publications
Proteases form one of the largest and more important groups of enzymes. They selectively
catalyze the hydrolysis of peptide bonds and can be divided into four major classes …

Facile Construction of New Hybrid Conjugation via Boron Cage Extension

F Sun, S Tan, HJ Cao, C Lu, D Tu… - Journal of the …, 2023 - ACS Publications
Aromatic polycyclic systems have been extensively utilized as structural subunits for the
preparation of various functional molecules. Currently, aromatics-based polycyclic systems …

Cobalt complexes as antiviral and antibacterial agents

EL Chang, C Simmers, DA Knight - Pharmaceuticals, 2010 - mdpi.com
Metal ion complexes are playing an increasing role in the development of antimicrobials. We
review here the antimicrobial properties of cobalt coordination complexes in oxidation state …

Supramolecular chemistry of anionic boron clusters and its applications in biology

J Cebula, K Fink, J Boratyński… - Coordination Chemistry …, 2023 - Elsevier
It has been almost 50 years since the term “supramolecular chemistry” was coined to
describe chemistry beyond the molecule. Since its beginning, supramolecular chemistry has …

Polyhedral boranes for medical applications: Current status and perspectives

IB Sivaev, VV Bregadze - European Journal of Inorganic …, 2009 - Wiley Online Library
This review focuses on the current status and perspectives of the application of polyhedral
boron hydrides in medicine. The main topics discussed are boron neutron capture therapy …